{"id":"W2149843865","doi":"10.2337/db10-1433","title":"Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans","year":2011,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Diabetes Association; Heart and Stroke Foundation of Canada","keywords":"Insulin resistance; Phenylbutyrate; Internal medicine; Endocrinology; Medicine; Endoplasmic reticulum; Insulin; Chemical chaperone; Unfolded protein response; Pharmacology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002143377,0.0004381676,0.0006102386,0.00024951,0.0001766968,0.0001652659,0.0001938385,0.0002781789,0.001009677],"category_scores_gemma":[0.0001922803,0.0001894419,0.0002070323,0.0001798797,0.0002891383,0.0001834677,0.0001562874,0.0005171246,0.0002008407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001097878,"about_ca_system_score_gemma":0.0002523664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004366417,"about_ca_topic_score_gemma":0.000695707,"domain_scores_codex":[0.9999309,0.00001988819,0.00000851636,0.00001333893,0.00001359642,0.00001380022],"domain_scores_gemma":[0.9998977,0.00001260749,0.00003623244,0.00001331165,0.00001034011,0.00002972562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03631207,0.003496464,0.004322988,0.0003668221,0.0002296942,0.0001592809,0.00003985963,0.0003429546,0.9113874,0.00005710908,0.0003229275,0.04296251],"study_design_scores_gemma":[0.01414122,0.2105127,0.1374231,0.0001976164,0.001132027,0.001456856,0.0002964255,0.002512128,0.6228171,0.000263448,0.009198316,0.0000491463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949909,0.003348995,0.0009569594,0.0001206586,0.00003550538,0.00004686759,0.00009993718,0.00004503083,0.0003550996],"genre_scores_gemma":[0.9939612,0.003067951,0.001483033,0.0001534367,0.00005385833,0.00007145767,0.0002360388,0.00001592029,0.0009570724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009677,"threshold_uncertainty_score":0.003377676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01923996804101822,"score_gpt":0.2128356736104474,"score_spread":0.1935957055694292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}