{"id":"W2149868956","doi":"10.1371/journal.pone.0047505","title":"In Vitro and Ex Vivo Inhibition of Human Telomerase by Anti-HIV Nucleoside Reverse Transcriptase Inhibitors (NRTIs) but Not by Non-NRTIs","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC","keywords":"Reverse transcriptase; Zidovudine; Telomerase; Abacavir; Didanosine; Efavirenz; Primer (cosmetics); Stavudine; Nucleoside Reverse Transcriptase Inhibitor; Zalcitabine; Reverse-transcriptase inhibitor; Telomere; Biology; Telomerase reverse transcriptase; Nucleotidyltransferase; Nevirapine; Molecular biology; Virology; Lamivudine; RNA; Chemistry; DNA; Biochemistry; Human immunodeficiency virus (HIV); Virus; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005517114,0.0004336541,0.0003735787,0.0002302818,0.0001147219,0.0003228108,0.0002487544,0.000234205,0.001559319],"category_scores_gemma":[0.0003376075,0.0002057977,0.0004030544,0.0003140629,0.0001292494,0.0001938857,0.0001194337,0.0007925731,0.0003731135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001951422,"about_ca_system_score_gemma":0.0002085396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007216646,"about_ca_topic_score_gemma":0.001003848,"domain_scores_codex":[0.9994481,0.0001646077,0.00009848955,0.00009398243,0.0001115307,0.00008322778],"domain_scores_gemma":[0.9996855,0.0001433072,0.00004945225,0.00005165695,0.00003860538,0.00003143017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000634198,0.0004495921,0.0002283251,0.0001328924,0.00003045356,0.00005442439,0.00004341326,0.000431943,0.9941832,0.0001319221,0.0002383671,0.003441312],"study_design_scores_gemma":[0.00007917502,0.004616119,0.002537026,0.00001477231,0.00004704302,0.0001542022,0.00002138181,0.002046493,0.9876533,0.00004376377,0.002777699,0.000008981777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781011,0.01261825,0.003730348,0.0001262785,0.00025214,0.00009663416,0.002188025,0.00007717414,0.002810118],"genre_scores_gemma":[0.9788876,0.007307828,0.004659167,0.0001031873,0.0001094394,0.0001580817,0.004495451,0.00002882629,0.004250417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001559319,"threshold_uncertainty_score":0.00521642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02198430106905863,"score_gpt":0.2340787151948968,"score_spread":0.2120944141258381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}