{"id":"W2149869301","doi":"10.1529/biophysj.104.057471","title":"Chevron Behavior and Isostable Enthalpic Barriers in Protein Folding: Successes and Limitations of Simple Gō-like Modeling","year":2005,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Cooperativity; Chevron (anatomy); Barnase; Chemistry; Protein folding; Native state; Folding (DSP implementation); Chemical physics; Thermodynamics; Kinetics; Statistical physics; Crystallography; Physics; Classical mechanics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006816998,0.00009365243,0.0001195338,0.00004046702,0.00006910605,0.00003018372,0.00006841865,0.00007811039,0.000002765275],"category_scores_gemma":[0.00006209793,0.00008413015,0.00003532688,0.00005532391,0.00005838136,0.00001551684,0.00005444543,0.0001133747,1.848152e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001070966,"about_ca_system_score_gemma":0.00004932785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001971963,"about_ca_topic_score_gemma":0.00005059625,"domain_scores_codex":[0.9994148,0.00002356659,0.0001779007,0.000145342,0.00008491451,0.0001534785],"domain_scores_gemma":[0.9996905,0.000008701258,0.00006377063,0.00008172338,0.00004760337,0.0001076545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003713472,0.00003428145,0.001255137,0.00001071585,0.00001072165,0.000002398191,0.00006892113,0.0004627329,0.9918454,0.0001572711,0.000007064668,0.006108206],"study_design_scores_gemma":[0.002604958,0.001023849,0.006862206,0.00008665727,0.0001082754,0.000157379,0.0007059109,0.03626969,0.9472345,0.001572331,0.00274858,0.0006257016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976969,0.000386214,0.001625266,0.00009387965,0.00001818299,0.0001272263,0.000008381345,0.000002509738,0.00004146772],"genre_scores_gemma":[0.9978212,0.0002563914,0.001708829,0.00003586564,0.0001307861,0.00001046582,0.000009096389,0.000009450049,0.00001796891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04461095,"threshold_uncertainty_score":0.3430728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428706399160786,"score_gpt":0.2542402976041376,"score_spread":0.2399532336125297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}