{"id":"W2149869428","doi":"10.1371/journal.pone.0137232","title":"Single-Cell Analysis and Next-Generation Immuno-Sequencing Show That Multiple Clones Persist in Patients with Chronic Lymphocytic Leukemia","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Manitoba; University of Alberta","funders":"","keywords":"IGHV@; Chronic lymphocytic leukemia; Biology; clone (Java method); Somatic evolution in cancer; Immunoglobulin heavy chain; Allelic exclusion; Dominance (genetics); Genetics; Macroglobulinemia; Gene rearrangement; Waldenstrom macroglobulinemia; Leukemia; Molecular biology; Antibody; Gene; Immunology; Multiple myeloma; T cell; Lymphoma; T-cell receptor; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003220819,0.0002618623,0.0006154522,0.0004940525,0.00008937499,0.0001021984,0.0001363452,0.0001472293,0.00004391031],"category_scores_gemma":[0.0002328492,0.0002231381,0.00007413931,0.0008713814,0.0001645589,0.0003340337,0.0001048383,0.0002191254,0.00002915852],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.1258122,"about_ca_system_score_gemma":0.01145473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004820169,"about_ca_topic_score_gemma":0.001894644,"domain_scores_codex":[0.9974267,0.00008882653,0.0003268325,0.0005395868,0.00109493,0.0005231053],"domain_scores_gemma":[0.9986007,0.0001184128,0.0001229717,0.0005552496,0.0003001119,0.0003026155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002398591,0.001789025,0.8120316,0.001202804,0.003004192,0.0002077158,0.00493056,0.003396431,0.1693181,0.000006416021,0.00009106092,0.001623476],"study_design_scores_gemma":[0.07594444,0.002253099,0.03288755,0.0006654857,0.002882402,0.00001812819,0.0007131576,0.7443314,0.1396391,0.000004894101,0.00003063081,0.0006298003],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997372,0.001383223,0.00006370052,0.00005078421,0.00002404033,0.0007134621,0.000007873441,0.00005959893,0.0003252645],"genre_scores_gemma":[0.9972419,0.00008737381,0.00163213,0.00008026192,0.0001296394,0.00004909563,0.0002481257,0.00004905689,0.0004824176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7791441,"threshold_uncertainty_score":0.9941494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1162650575618516,"score_gpt":0.2430151440787288,"score_spread":0.1267500865168772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}