{"id":"W2149869428","doi":"10.1371/journal.pone.0137232","title":"Single-Cell Analysis and Next-Generation Immuno-Sequencing Show That Multiple Clones Persist in Patients with Chronic Lymphocytic Leukemia","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Manitoba; University of Alberta","funders":"","keywords":"IGHV@; Chronic lymphocytic leukemia; Biology; clone (Java method); Somatic evolution in cancer; Immunoglobulin heavy chain; Allelic exclusion; Dominance (genetics); Genetics; Macroglobulinemia; Gene rearrangement; Waldenstrom macroglobulinemia; Leukemia; Molecular biology; Antibody; Gene; Immunology; Multiple myeloma; T cell; Lymphoma; T-cell receptor; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002854559,0.0002381329,0.000374251,0.0008506869,0.0003590237,0.0005210355,0.0002033172,0.000423158,0.001471258],"category_scores_gemma":[0.001538727,0.0001468093,0.0001035096,0.0006305675,0.0003239024,0.0003006949,0.000211851,0.0002900574,0.0004573301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002115797,"about_ca_system_score_gemma":0.000127566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006786434,"about_ca_topic_score_gemma":0.0008072736,"domain_scores_codex":[0.9996833,0.00003447578,0.00003199356,0.00009740922,0.000092135,0.00006076646],"domain_scores_gemma":[0.9991041,0.0004047093,0.000192403,0.00008002007,0.0001100844,0.0001087168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003483545,0.00005470556,0.9196509,0.00004019427,0.00002154302,0.001659083,0.0003558477,0.00008541518,0.05079771,0.00006032067,0.0002922184,0.02663381],"study_design_scores_gemma":[0.00004026948,0.0004508104,0.9489219,0.00001600818,0.000079828,0.02747339,0.000423821,0.0007807192,0.01890477,0.0001903721,0.002703137,0.00001491428],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984908,0.000654833,0.0002859579,0.00003206121,0.000003621807,0.000005393081,0.00008612076,0.00001572404,0.0004255323],"genre_scores_gemma":[0.9991686,0.0001703723,0.0002610401,0.00003541128,0.00001602386,0.00001000552,0.000179985,0.000004624026,0.0001538415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001471258,"threshold_uncertainty_score":0.004921854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1162650575618516,"score_gpt":0.2430151440787288,"score_spread":0.1267500865168772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}