{"id":"W2149879159","doi":"10.2174/138920112800958751","title":"Targeted Oncolytic Herpes Simplex Viruses for Aggressive Cancers","year":2012,"lang":"en","type":"review","venue":"Current Pharmaceutical Biotechnology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Oncolytic virus; Herpes simplex virus; Virology; Medicine; Cancer research; Virotherapy; Viral therapy; Immunology; Coronavirus disease 2019 (COVID-19); Virus; Internal medicine; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0004299393,0.0008475696,0.001452818,0.0003607634,0.0001855976,0.00003725276,0.00124318,0.001778218,0.0001931544],"category_scores_gemma":[0.0002763809,0.0007334603,0.0007954454,0.0004726282,0.0007790893,0.000006712523,0.0005736994,0.0009775024,0.0001806903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003432988,"about_ca_system_score_gemma":0.001083608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003395307,"about_ca_topic_score_gemma":0.00002353261,"domain_scores_codex":[0.9960089,0.0003108954,0.0007610639,0.001161016,0.0002798624,0.001478293],"domain_scores_gemma":[0.9978471,0.0001537597,0.0005315428,0.0009197803,0.0001446205,0.000403234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004687675,0.0001944758,6.059685e-7,0.004235892,0.0005297827,0.000004704357,0.000003983013,0.000001094648,0.002602181,0.00009918171,0.002949807,0.9889095],"study_design_scores_gemma":[0.0008750435,0.0009779669,6.135187e-8,0.0007800705,0.0007926605,0.00003011189,0.000005367742,0.000021993,0.05178019,0.00003818723,0.9439569,0.0007415098],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002715783,0.9946853,0.000345196,0.0001531608,0.001092303,0.002498968,0.0007915717,0.0001336338,0.0000282924],"genre_scores_gemma":[0.0003094015,0.9956123,0.000164737,0.0001993855,0.001213864,0.001323333,0.0009273419,0.0001759908,0.00007366634],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.988168,"threshold_uncertainty_score":0.9995177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1831056471223759,"score_gpt":0.4847030628380432,"score_spread":0.3015974157156673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}