{"id":"W2149882720","doi":"10.1186/1476-4598-9-131","title":"Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives","year":2010,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Allard Foundation; Alberta Cancer Foundation; Ministry of Advanced Education, Government of Alberta; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense","keywords":"Tubulin; Colchicine; Isotype; Biology; Microtubule; Gene isoform; Cytotoxicity; Cancer cell; Cytotoxic T cell; Cancer research; Cancer; Molecular biology; Cell biology; Biochemistry; Antibody; Immunology; Genetics; In vitro; Gene; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002879378,0.0003252482,0.0002223027,0.0004590282,0.000118343,0.0001767339,0.0001610165,0.0002366741,0.0007917442],"category_scores_gemma":[0.000450736,0.00008265379,0.0001957402,0.0002897241,0.0001997836,0.0001017304,0.00007977541,0.0002273512,0.0001025154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003461663,"about_ca_system_score_gemma":0.0001087498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005863956,"about_ca_topic_score_gemma":0.0008458275,"domain_scores_codex":[0.9998395,0.00003953327,0.00001301406,0.00003087835,0.00006478551,0.00001214885],"domain_scores_gemma":[0.9996644,0.0001797408,0.00006032517,0.00002854978,0.00005093005,0.00001614745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002353895,0.00003520921,0.005077805,0.0001097067,0.00003855427,0.00004097663,0.00002372206,0.009206348,0.9777997,0.00009122171,0.00004503807,0.007296293],"study_design_scores_gemma":[0.000006141614,0.0004524129,0.0239955,0.000004768984,0.00004003961,0.0001267689,0.00001555871,0.03424121,0.9406203,0.00008075391,0.0004062775,0.00001025047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738538,0.000807299,0.0233133,0.00003768854,0.000009859379,0.00004063309,0.0007144662,0.0001418613,0.001081057],"genre_scores_gemma":[0.990697,0.0002996417,0.007739151,0.0000120396,0.000003373109,0.00004926952,0.000702582,0.000009227667,0.0004877073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007917442,"threshold_uncertainty_score":0.002648711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01734089961551212,"score_gpt":0.3073775470576874,"score_spread":0.2900366474421753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}