{"id":"W2149886203","doi":"10.3987/com-04-s(p)47","title":"Discovery and Synthesis of a Potent, Selective and Orally Bioavailable EP4 Receptor Agonist","year":2004,"lang":"en","type":"article","venue":"Heterocycles","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Synthon; Agonist; Bioavailability; Receptor; Stereochemistry; Chemical synthesis; Lactam; Cyclopentanone; Pharmacology; Prostaglandin; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001140545,0.0001392794,0.0003148791,0.00008312716,0.00007115063,0.00002541698,0.00003309674,0.00008071678,0.000006875838],"category_scores_gemma":[0.0001708201,0.0001104669,0.00004721112,0.00007237615,0.0001750798,0.0001401875,0.00003654337,0.0000889471,0.00001173695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004162675,"about_ca_system_score_gemma":0.00005312046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001426439,"about_ca_topic_score_gemma":0.00003450622,"domain_scores_codex":[0.9992453,0.00003044786,0.000175429,0.0002272724,0.0001325351,0.0001889684],"domain_scores_gemma":[0.9995062,0.00008374371,0.0001286539,0.0001380233,0.00003756131,0.0001058275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001491028,0.0005154852,0.1551158,0.001883553,0.0003569121,0.0001316978,0.001335478,0.000005985364,0.8128402,0.000639163,0.0009913545,0.02469329],"study_design_scores_gemma":[0.002259073,0.0005712692,0.09545662,0.000662186,0.0001582487,0.000123827,0.0002114517,0.00002206282,0.8992773,0.0002797605,0.0007394222,0.0002388046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980677,0.0007963869,0.00003760703,0.0002337594,0.00006917275,0.0002344449,0.00001782677,0.00003003357,0.0005130797],"genre_scores_gemma":[0.9985042,0.0004121822,0.0007647733,0.00008550011,0.00008348902,0.00002073318,0.000004294641,0.00001969279,0.0001051883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08643704,"threshold_uncertainty_score":0.4504711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007110738723465218,"score_gpt":0.2241480580072254,"score_spread":0.2170373192837602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}