{"id":"W2149899785","doi":"10.1093/humrep/des072","title":"Patterns of placental development evaluated by X chromosome inactivation profiling provide a basis to evaluate the origin of epigenetic variation","year":2012,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; Epigenetics; Trophoblast; Genomic imprinting; DNA methylation; X-inactivation; Amnion; Placenta; Genetics; Mesenchyme; XIST; Fetal membrane; Inner cell mass; Differentially methylated regions; X chromosome; Embryogenesis; Fetus; Gene; Embryo; Blastocyst; Gene expression; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007119981,0.0001140776,0.0001304925,0.0000393503,0.0001023649,0.000008808532,0.0001073593,0.0000679544,0.00005524054],"category_scores_gemma":[0.0001333184,0.0000901537,0.00004558594,0.00009023244,0.00003305872,0.00001056575,0.00005611682,0.00005184258,0.000004679457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003312018,"about_ca_system_score_gemma":0.00005226202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003111455,"about_ca_topic_score_gemma":0.000007355617,"domain_scores_codex":[0.9987472,0.0001167461,0.0004335532,0.0002770534,0.0002651113,0.0001603282],"domain_scores_gemma":[0.9992393,0.00001069188,0.0001941837,0.0002963659,0.0002107162,0.00004877519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006577488,0.0002146197,0.01195093,0.00006352752,0.00004405267,3.342673e-8,0.0006760855,0.00009165971,0.9812387,0.0000834399,0.00009571017,0.005475462],"study_design_scores_gemma":[0.0002831965,0.0002780321,0.1033735,0.00002258861,0.00002853123,0.000003250765,0.0003498619,0.00001935894,0.8938046,0.0000304331,0.001702183,0.00010442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997636,0.0001546917,0.001296289,0.0001337349,0.0001820344,0.0004672819,0.000008773842,0.000008710675,0.000112545],"genre_scores_gemma":[0.9984088,0.00001776912,0.0003679731,0.00003794952,0.0002513502,0.00007116536,0.0001649593,0.00001215058,0.0006679107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0914226,"threshold_uncertainty_score":0.3676361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03175257630719083,"score_gpt":0.3060842090143819,"score_spread":0.2743316327071911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}