{"id":"W2149899785","doi":"10.1093/humrep/des072","title":"Patterns of placental development evaluated by X chromosome inactivation profiling provide a basis to evaluate the origin of epigenetic variation","year":2012,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; Epigenetics; Trophoblast; Genomic imprinting; DNA methylation; X-inactivation; Amnion; Placenta; Genetics; Mesenchyme; XIST; Fetal membrane; Inner cell mass; Differentially methylated regions; X chromosome; Embryogenesis; Fetus; Gene; Embryo; Blastocyst; Gene expression; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001986163,0.00017036,0.0001565342,0.0007759554,0.0001476391,0.0002966611,0.0001453137,0.0001691951,0.001191187],"category_scores_gemma":[0.0004414414,0.0001358936,0.00008820975,0.0004546989,0.0002480389,0.0001495601,0.0002527016,0.0002646456,0.0001988926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001650579,"about_ca_system_score_gemma":0.00009444235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005945915,"about_ca_topic_score_gemma":0.001083571,"domain_scores_codex":[0.9998717,0.00001823567,0.00001109705,0.00004108923,0.00004030714,0.00001753223],"domain_scores_gemma":[0.9996494,0.00009222471,0.0001347139,0.0000340928,0.00005535876,0.00003419198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001289149,0.000008752571,0.06588835,0.00003404821,0.00002235354,0.0001197382,0.0001232371,0.00007114179,0.9286625,0.00008374736,0.00001853685,0.004838613],"study_design_scores_gemma":[0.000003177857,0.0001610724,0.8288983,0.000007912459,0.00003781518,0.0007803824,0.0001817666,0.0005750029,0.1683698,0.0001554383,0.0008239074,0.000005381886],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926247,0.0005393068,0.005103657,0.00001401252,0.00000262565,0.00002289754,0.0004585279,0.0000386092,0.001195568],"genre_scores_gemma":[0.9945776,0.000413437,0.004137115,0.00001043489,0.000003015236,0.00002274654,0.0003639776,0.00001571302,0.0004559734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001191187,"threshold_uncertainty_score":0.003984928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03175257630719083,"score_gpt":0.3060842090143819,"score_spread":0.2743316327071911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}