{"id":"W2149925047","doi":"10.1111/j.1462-2920.2012.02842.x","title":"Intraclonal diversity of the <i>Pseudomonas aeruginosa</i> cystic fibrosis airway isolates TBCF10839 and TBCF121838: distinct signatures of transcriptome, proteome, metabolome, adherence and pathogenicity despite an almost identical genome sequence","year":2012,"lang":"en","type":"article","venue":"Environmental Microbiology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Biology; Genetics; Pathogenicity island; Prophage; Whole genome sequencing; Genome; Transcriptome; Genomic island; Frameshift mutation; Multilocus sequence typing; Virulence; Gene; Microbiology; Mutation; Genotype; Escherichia coli; Bacteriophage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008092465,0.0002192093,0.0002850107,0.0003207019,0.0002331401,0.0003442293,0.0001300463,0.0003733067,0.0004931962],"category_scores_gemma":[0.0004026314,0.0001206164,0.0002213393,0.0003910711,0.0001809385,0.000142404,0.0002561297,0.0002895622,0.0002006268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001614308,"about_ca_system_score_gemma":0.0001403698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003505908,"about_ca_topic_score_gemma":0.002705457,"domain_scores_codex":[0.9998016,0.00001682165,0.00001534807,0.0000702586,0.0000480486,0.00004797767],"domain_scores_gemma":[0.9997271,0.00004752184,0.0000860273,0.00002430998,0.00005912457,0.00005589006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001856173,0.00002129965,0.02368832,0.000026227,0.00001617422,0.0002013583,0.0001551532,0.00002442781,0.974272,0.00001223958,0.00002876011,0.001368489],"study_design_scores_gemma":[0.00001756073,0.0006224483,0.9157745,0.00001202745,0.00008347832,0.002744081,0.0006190878,0.0002948036,0.07875758,0.00003245759,0.00102885,0.00001316661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999492,0.00004787681,0.00006364727,0.00001417991,0.000001319411,0.00000534782,0.0002462254,0.000002584193,0.000126765],"genre_scores_gemma":[0.9979799,0.0000566518,0.0002915967,0.00003005757,0.000004628437,0.00001697817,0.001345657,0.000005937587,0.0002686209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003505908,"threshold_uncertainty_score":0.006971002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007214860356604433,"score_gpt":0.1970936965323184,"score_spread":0.1898788361757139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}