{"id":"W2149959418","doi":"10.1530/eje-11-0773","title":"Safety, tolerability, and pharmacokinetics of a single dose of pasireotide long-acting release in healthy volunteers: a single-center Phase I study","year":2012,"lang":"en","type":"article","venue":"European Journal of Endocrinology","topic":"Glycogen Storage Diseases and Myoclonus","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Micropharma (Canada)","funders":"Novartis Pharmaceuticals Corporation","keywords":"Pasireotide; Tolerability; Medicine; Pharmacokinetics; Adverse effect; Postprandial; Internal medicine; Gastroenterology; Pharmacology; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005807269,0.0001777819,0.0006732112,0.0002979502,0.00002740264,0.000005679261,0.0001277536,0.00001735743,0.00007137516],"category_scores_gemma":[0.0004360543,0.0001548956,0.000137294,0.0001681796,0.0001486667,0.000124045,0.0001286362,0.00032564,0.000002581209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007865543,"about_ca_system_score_gemma":0.00005983714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002564386,"about_ca_topic_score_gemma":0.000007077945,"domain_scores_codex":[0.997308,0.0006404747,0.001221391,0.0001699399,0.0002298229,0.0004303893],"domain_scores_gemma":[0.9984184,0.0001304313,0.000653046,0.0002242573,0.00024423,0.0003296197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02786933,0.04010599,0.7519775,0.0006017955,0.0005200616,0.01964583,0.005702557,0.00003299961,0.06088165,0.00001955864,0.0001893021,0.09245343],"study_design_scores_gemma":[0.1765096,0.1019451,0.6320625,0.001682148,0.002319078,0.04263315,0.0125864,0.0001134549,0.01438773,0.00001562642,0.01484999,0.0008952452],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995654,0.002456687,0.0001426323,0.0003102299,0.0003305658,0.0003576863,0.00001386201,0.000008087382,0.0007262427],"genre_scores_gemma":[0.9989859,0.0001673204,0.0003619152,0.0002027502,0.0002293858,8.913422e-7,0.000002860581,0.00003270453,0.00001624834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1486403,"threshold_uncertainty_score":0.6316459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05204821365214508,"score_gpt":0.332620177143884,"score_spread":0.280571963491739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}