{"id":"W2149966580","doi":"10.1002/jms.1205","title":"Evaluation of relative DNA binding affinities of anthrapyrazoles by electrospray ionization mass spectrometry","year":2007,"lang":"en","type":"article","venue":"Journal of Mass Spectrometry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of General Medical Sciences; Welch Foundation","keywords":"Chemistry; Electrospray ionization; Mass spectrometry; DNA; Affinities; Dissociation (chemistry); Electrospray; Binding affinities; Ligand (biochemistry); Chromatography; Stereochemistry; Organic chemistry; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002681845,0.0002031403,0.0003924454,0.0004037371,0.00005667379,0.0000159331,0.0002787242,0.0002450873,0.0001676666],"category_scores_gemma":[0.0005869176,0.0001927317,0.0002260946,0.0005968176,0.0001511511,0.00003324974,0.00003334209,0.0002715013,0.000001360609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001635147,"about_ca_system_score_gemma":0.0002100387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001757221,"about_ca_topic_score_gemma":0.000001289414,"domain_scores_codex":[0.9975186,0.00009717521,0.0008344518,0.0002076578,0.001034679,0.0003074511],"domain_scores_gemma":[0.9974696,0.00007123913,0.00129386,0.0002381232,0.0008323285,0.00009481658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001989721,0.0001399581,0.005496185,0.00003839948,0.000336253,0.000003677066,0.00005219435,0.00001561234,0.9924633,0.0001340443,0.0005853141,0.0005361065],"study_design_scores_gemma":[0.001180914,0.0008513767,0.002786535,0.00006282681,0.0002349532,0.00005075622,0.0006348473,0.00002607488,0.9928505,0.0009820489,0.0001624022,0.0001767413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665313,0.003197764,0.02546849,0.00007162459,0.0001888593,0.00009260513,0.00002585221,0.000005161838,0.004418355],"genre_scores_gemma":[0.9908267,0.0007997594,0.007869625,0.00001404263,0.0002734696,7.823491e-7,0.00004305374,0.00002967165,0.0001428726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02429544,"threshold_uncertainty_score":0.785937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01108982045100366,"score_gpt":0.2678603212793914,"score_spread":0.2567705008283878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}