{"id":"W2149983483","doi":"10.3747/co.20.1497","title":"Denosumab and Giant Cell Tumour of Bone—A Review and Future Management Considerations","year":2013,"lang":"en","type":"review","venue":"Current Oncology","topic":"Bone Tumor Diagnosis and Treatments","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Denosumab; Medicine; Giant cell; RANKL; Osteoclast; Giant-cell tumor of bone; Cancer research; Pathology; Activator (genetics); Receptor; Internal medicine; Osteoporosis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001441237,0.0003522445,0.002621986,0.0001467739,0.00005443272,0.00001122193,0.00003912009,0.0001547619,0.0003449841],"category_scores_gemma":[0.00001940536,0.0002438967,0.0002036174,0.0001018407,0.0001134099,0.00003016641,0.0001192775,0.0003012017,0.00005417534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001127917,"about_ca_system_score_gemma":0.0001713849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004041172,"about_ca_topic_score_gemma":0.000003341752,"domain_scores_codex":[0.9983853,0.0001498919,0.0007295831,0.0004064704,0.0001202197,0.0002085783],"domain_scores_gemma":[0.9988389,0.0001396294,0.0004784371,0.0002865886,0.00008561073,0.0001708437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00000136303,0.0005347204,0.00003089556,0.137857,0.0001890284,0.0001101293,0.00001526737,8.149662e-10,9.750826e-8,0.0007647504,0.02548419,0.8350125],"study_design_scores_gemma":[0.0009030249,0.0002989339,0.0002482655,0.0229356,0.0109369,0.0006912219,0.00001712292,2.979238e-7,4.519624e-7,0.00005006793,0.9637556,0.0001624948],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001877526,0.9937279,9.265605e-7,0.0008453192,0.00038296,0.002842095,0.00005300167,0.00001550719,0.002113481],"genre_scores_gemma":[0.00001450675,0.9980381,0.0006491156,0.0001293602,0.0001456521,0.0005936855,0.0001407599,0.0000286625,0.0002601855],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9382714,"threshold_uncertainty_score":0.9945818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1192975730936035,"score_gpt":0.4197027516051755,"score_spread":0.3004051785115721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}