{"id":"W2149998180","doi":"10.1128/mcb.25.8.3348-3356.2005","title":"Posttranscriptional Downregulation of c-IAP2 by the Ubiquitin Protein Ligase c-IAP1 In Vivo","year":2005,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Ubiquitin ligase; Biology; Inhibitor of apoptosis; Ubiquitin; XIAP; Downregulation and upregulation; Signal transducing adaptor protein; Cell biology; TRAF2; Ectopic expression; Molecular biology; Apoptosis; Signal transduction; Programmed cell death; Caspase; Biochemistry; Gene; Tumor necrosis factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002841368,0.0004315118,0.0002403691,0.0002224554,0.0002231943,0.0005869499,0.0002808317,0.0002919947,0.00117616],"category_scores_gemma":[0.0002184355,0.0002230499,0.0002592386,0.0001491997,0.0003320926,0.0002612765,0.0002905271,0.0008251726,0.0007061653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006172304,"about_ca_system_score_gemma":0.0003037349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000418956,"about_ca_topic_score_gemma":0.0005443749,"domain_scores_codex":[0.9997563,0.00003244396,0.00001896052,0.00007005657,0.00004928399,0.00007287815],"domain_scores_gemma":[0.999705,0.00005007162,0.00009010434,0.00005948977,0.00002765811,0.0000676425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001820943,0.00003545633,0.0001339893,0.00002048832,0.00000495669,0.00004163196,0.000006968913,0.00006343898,0.9985885,0.0001395118,0.00004707241,0.0007357643],"study_design_scores_gemma":[0.00002174072,0.0001205106,0.002618443,0.000004238266,0.00001010396,0.000239547,0.00001472309,0.001104491,0.9942362,0.00005857892,0.001567845,0.000003708496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906494,0.00253526,0.004274749,0.0001707325,0.00006049079,0.00002767862,0.0004640229,0.0001520791,0.001665645],"genre_scores_gemma":[0.9934361,0.0006682866,0.001269711,0.00007648449,0.00002074341,0.00003436832,0.000894149,0.00004412231,0.003555958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00117616,"threshold_uncertainty_score":0.004478395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004304112179011999,"score_gpt":0.2079115997712753,"score_spread":0.2036074875922633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}