{"id":"W2149998463","doi":"10.1017/s0031182002002524","title":"Consequence of Hoechst 33342-mediated <i>Leishmania</i> DNA topoisomerase-I inhibition on parasite replication","year":2003,"lang":"en","type":"article","venue":"Parasitology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval","funders":"","keywords":"Biology; Topoisomerase; Leishmania; Leishmania donovani; Kinetoplastida; Leishmania major; DNA; Apoptosis; DNA damage; DNA replication; Parasite hosting; Molecular biology; Leishmania mexicana; Microbiology; Leishmaniasis; Biochemistry; Genetics; Immunology; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001392716,0.0003312164,0.0001969424,0.0001048136,0.0001679449,0.0002268744,0.000187646,0.0002224212,0.002117814],"category_scores_gemma":[0.0001945479,0.0001305591,0.0001120791,0.00008557412,0.0001761034,0.0001904821,0.0001404411,0.0005046459,0.0003776694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001918525,"about_ca_system_score_gemma":0.0002001033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008323491,"about_ca_topic_score_gemma":0.0008172094,"domain_scores_codex":[0.999816,0.00004269067,0.00001291995,0.00002711985,0.00004232389,0.00005907712],"domain_scores_gemma":[0.99981,0.00006270772,0.00004212375,0.00002622849,0.0000271198,0.00003178236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001353018,0.00002092836,0.000126044,0.00003368276,0.000004597031,0.00006413632,0.00001193195,0.00005246304,0.9983777,0.0001201531,0.00005125815,0.001001764],"study_design_scores_gemma":[0.000009126649,0.0002300198,0.0008659491,0.000002146191,0.000005889057,0.00006652281,0.000009725686,0.0002757451,0.9976197,0.00003063426,0.0008828155,0.000001667047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917204,0.001890146,0.002732269,0.0001615733,0.00004166767,0.00002878643,0.0003803319,0.0001292155,0.002915717],"genre_scores_gemma":[0.994941,0.0008120443,0.001352376,0.00004366642,0.00001247235,0.0000230781,0.000411824,0.00001676892,0.00238678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002117814,"threshold_uncertainty_score":0.007084787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486542741561567,"score_gpt":0.2920701547094322,"score_spread":0.2772047272938166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}