{"id":"W2149998463","doi":"10.1017/s0031182002002524","title":"Consequence of Hoechst 33342-mediated <i>Leishmania</i> DNA topoisomerase-I inhibition on parasite replication","year":2003,"lang":"en","type":"article","venue":"Parasitology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval","funders":"","keywords":"Biology; Topoisomerase; Leishmania; Leishmania donovani; Kinetoplastida; Leishmania major; DNA; Apoptosis; DNA damage; DNA replication; Parasite hosting; Molecular biology; Leishmania mexicana; Microbiology; Leishmaniasis; Biochemistry; Genetics; Immunology; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001954089,0.0001510261,0.0001947565,0.00005635017,0.00006283353,0.000006930355,0.00009552459,0.0001927596,0.00003812012],"category_scores_gemma":[0.0001086274,0.0001558362,0.00007022379,0.0001129274,0.0001191077,0.00000330664,0.00001690959,0.00008547604,0.00003548292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002076038,"about_ca_system_score_gemma":0.00008007519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002527057,"about_ca_topic_score_gemma":0.00004191664,"domain_scores_codex":[0.9988782,0.00009100278,0.0002625512,0.0004398573,0.0001006662,0.0002276793],"domain_scores_gemma":[0.999074,0.00003326048,0.0001674479,0.0005650637,0.00009448212,0.00006577928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001232567,0.00008881672,0.001355997,0.00001288094,0.00003325723,0.00001139322,0.00001974633,0.00001457696,0.9915493,0.005276603,0.0003470114,0.001167143],"study_design_scores_gemma":[0.0006112421,0.0004595331,0.001837998,0.00001279443,0.00001750246,0.00010793,0.00002054747,0.000009221896,0.9684701,0.0008776184,0.02741371,0.0001618142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941822,0.0003549215,0.00165366,0.0002816222,0.0002430996,0.0002228066,0.00003590443,0.00001748534,0.003008253],"genre_scores_gemma":[0.9975401,0.0003180328,0.0002616668,0.001461774,0.00005487376,0.000049652,0.0001834251,0.000019028,0.0001114599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0270667,"threshold_uncertainty_score":0.6354817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486542741561567,"score_gpt":0.2920701547094322,"score_spread":0.2772047272938166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}