{"id":"W2150014596","doi":"10.4049/jimmunol.174.12.7986","title":"Mechanisms of Mucosal and Parenteral Tuberculosis Vaccinations: Adenoviral-Based Mucosal Immunization Preferentially Elicits Sustained Accumulation of Immune Protective CD4 and CD8 T Cells within the Airway Lumen","year":2005,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Colorado State University","keywords":"Immune system; Immunology; Tuberculosis vaccines; Spleen; Immunization; CD8; Vaccination; CTL*; Medicine; T cell; Population; Mycobacterium tuberculosis; Biology; Tuberculosis; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006120011,0.0006002196,0.0005692163,0.0002405864,0.0001403193,0.0005716395,0.0003869186,0.0008986986,0.001326323],"category_scores_gemma":[0.0002908045,0.000254525,0.0004918449,0.00008956678,0.0004564401,0.0006537968,0.0004885237,0.001192856,0.0005128341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003114229,"about_ca_system_score_gemma":0.0002374154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001311995,"about_ca_topic_score_gemma":0.0001462495,"domain_scores_codex":[0.9995255,0.000104171,0.00003203422,0.0001181145,0.00009062311,0.0001294014],"domain_scores_gemma":[0.9997845,0.00004051438,0.000070246,0.00004230439,0.00002356207,0.00003889563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003506964,0.0001523387,0.0009661066,0.0004006127,0.00002213937,0.00009395643,0.00005337836,0.0001497797,0.9814068,0.000395436,0.00008502775,0.01592364],"study_design_scores_gemma":[0.0001937732,0.006876337,0.01721609,0.0001217866,0.0001207065,0.001785573,0.0001182672,0.002551884,0.9662841,0.000458167,0.00425936,0.00001395943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.966813,0.01358044,0.01491972,0.0003806413,0.000146419,0.0002652823,0.0001506651,0.0004017334,0.003342054],"genre_scores_gemma":[0.9934332,0.001582092,0.00315894,0.0001491755,0.00005828285,0.0001450657,0.0001103357,0.00001682697,0.001345981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001326323,"threshold_uncertainty_score":0.00443697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01279933480262201,"score_gpt":0.2530242188560505,"score_spread":0.2402248840534285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}