{"id":"W2150037272","doi":"10.1089/ten.tec.2009.0228","title":"Large-Scale Expansion of Pluripotent Human Embryonic Stem Cells in Stirred-Suspension Bioreactors","year":2009,"lang":"en","type":"article","venue":"Tissue Engineering Part C Methods","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research; University of Calgary; California HIV/AIDS Research Program","keywords":"Bioreactor; Embryonic stem cell; Induced pluripotent stem cell; Laboratory flask; Suspension culture; Cell biology; Biology; Stem cell; Flow cytometry; Embryoid body; Cell culture; Regenerative medicine; Mesenchymal stem cell; Chemistry; Molecular biology; Biochemistry; Genetics; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00115009,0.0002454426,0.0003557033,0.0001927055,0.00004149452,0.00001386093,0.0002747081,0.0002228206,0.00002754412],"category_scores_gemma":[0.00004089198,0.0002475797,0.00009542303,0.0002550643,0.00002675166,0.000007729932,0.0001319323,0.0002217853,0.00001056927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004121548,"about_ca_system_score_gemma":0.00003829118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001119795,"about_ca_topic_score_gemma":0.000005410057,"domain_scores_codex":[0.9981489,0.0002185594,0.0004065059,0.0004620757,0.0002568235,0.0005071867],"domain_scores_gemma":[0.9990935,0.00003973432,0.00008982017,0.000567987,0.00005987122,0.0001490429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002350978,0.0000865027,0.00005977607,0.0000579648,0.00001291048,0.00001158626,0.0001050483,0.005193924,0.9888709,0.00002049193,0.0003623127,0.005195134],"study_design_scores_gemma":[0.0004860289,0.0003371274,0.001484917,0.00008604315,0.000009976375,0.000005980599,0.0000446083,0.001958012,0.9534534,0.000008435467,0.04188824,0.0002372104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9557696,0.001231558,0.04208425,0.00006343942,0.0003098242,0.0003406365,0.0000139516,0.00003681652,0.0001499079],"genre_scores_gemma":[0.9645711,0.0002026725,0.03282818,0.00001819751,0.0001530775,0.00001578033,0.00005229229,0.00004797923,0.002110765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04152592,"threshold_uncertainty_score":0.9999976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02275238238070831,"score_gpt":0.3285248912736676,"score_spread":0.3057725088929593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}