{"id":"W2150111967","doi":"10.1086/375033","title":"Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies","year":2003,"lang":"en","type":"review","venue":"The American Journal of Human Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3685,"is_retracted":false,"has_abstract":false,"ca_institutions":"Coalition for Research in Women's Health; University of Toronto","funders":"National Cancer Institute","keywords":"Breast cancer; Ovarian cancer; Family history; Medicine; Germline mutation; Oncology; Cancer; Context (archaeology); Relative risk; Internal medicine; Incidence (geometry); Mutation; BRCA mutation; Gynecology; Confidence interval; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001745138,0.0006309971,0.002006597,0.003620426,0.000132639,0.0007366121,0.0007016951,0.0004318813,0.001058541],"category_scores_gemma":[0.00339914,0.0002849838,0.001152724,0.004191707,0.0001713585,0.0006129941,0.0004156746,0.0003084883,0.0002487895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003155509,"about_ca_system_score_gemma":0.0004839704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009507979,"about_ca_topic_score_gemma":0.001932093,"domain_scores_codex":[0.9991178,0.0001923676,0.0001535203,0.0002640823,0.0002278389,0.00004437161],"domain_scores_gemma":[0.9968402,0.002168534,0.0004561606,0.00009944159,0.0003513669,0.00008422581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001361798,0.00002646182,0.2027939,0.01412683,0.01000159,0.001720537,0.0001785682,0.001183595,0.001624872,0.0003987264,0.006947844,0.7596353],"study_design_scores_gemma":[0.0002219599,0.0008926312,0.7565011,0.007667027,0.04583836,0.04750998,0.0006675305,0.001022717,0.002887801,0.00225079,0.1343562,0.0001837772],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01605857,0.9815026,0.0008928601,0.0001261789,0.00005602094,0.000006906058,0.0005860969,0.00002586761,0.0007450363],"genre_scores_gemma":[0.1236177,0.872368,0.002047716,0.0001383782,0.0002166598,0.00002100332,0.001119081,0.00001478771,0.0004566885],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003620426,"threshold_uncertainty_score":0.009229243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0737969457601159,"score_gpt":0.3703780233766856,"score_spread":0.2965810776165697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}