{"id":"W2150115389","doi":"10.1158/1078-0432.ccr-10-1893","title":"Phase I Study of Decitabine in Combination with Vorinostat in Patients with Advanced Solid Tumors and Non-Hodgkin's Lymphomas","year":2011,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Decitabine; Medicine; Vorinostat; Neutropenia; Tolerability; Febrile neutropenia; Leukopenia; Internal medicine; Maximum tolerated dose; Adverse effect; Pharmacokinetics; Gastroenterology; Pharmacology; Oncology; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006445088,0.0008079542,0.001960869,0.0002938501,0.0002795575,0.0005314256,0.0005621202,0.0005063957,0.002109931],"category_scores_gemma":[0.00046978,0.0003513226,0.000610122,0.0004020804,0.0005288737,0.0003613323,0.0002690697,0.001666266,0.0004009349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006282368,"about_ca_system_score_gemma":0.001183458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00047135,"about_ca_topic_score_gemma":0.001183516,"domain_scores_codex":[0.9997334,0.0001132457,0.00001810054,0.00004244391,0.00003865461,0.00005423649],"domain_scores_gemma":[0.9995379,0.00007643474,0.0001099082,0.00003222136,0.0000258556,0.0002177554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4533753,0.08098493,0.02417185,0.001681017,0.002077268,0.0009154141,0.0004600761,0.005310019,0.1871082,0.0003091758,0.002786249,0.2408204],"study_design_scores_gemma":[0.2082616,0.7372478,0.02277401,0.00005993912,0.0007360551,0.001258089,0.00007356688,0.001502133,0.02256146,0.0001449731,0.005351809,0.00002843726],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948438,0.002858086,0.0004084554,0.0001291896,0.00003524715,0.0007551498,0.0002095645,0.00003932535,0.0007211505],"genre_scores_gemma":[0.9939756,0.001934034,0.001420987,0.0002024334,0.00008780531,0.0008052917,0.0007053111,0.00001321523,0.0008554131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002109931,"threshold_uncertainty_score":0.007058442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0606253614671827,"score_gpt":0.4430309267504193,"score_spread":0.3824055652832365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}