{"id":"W2150115389","doi":"10.1158/1078-0432.ccr-10-1893","title":"Phase I Study of Decitabine in Combination with Vorinostat in Patients with Advanced Solid Tumors and Non-Hodgkin's Lymphomas","year":2011,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Decitabine; Medicine; Vorinostat; Neutropenia; Tolerability; Febrile neutropenia; Leukopenia; Internal medicine; Maximum tolerated dose; Adverse effect; Pharmacokinetics; Gastroenterology; Pharmacology; Oncology; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001345413,0.000132669,0.0003228154,0.000237993,0.00004813474,0.000009470723,0.0002277605,0.0001024898,0.00001826232],"category_scores_gemma":[0.0003374973,0.000105395,0.00002136373,0.0005070248,0.0004524819,0.000013997,0.0001950809,0.0003739152,0.000001388937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007151637,"about_ca_system_score_gemma":0.0003453097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008374581,"about_ca_topic_score_gemma":0.003061478,"domain_scores_codex":[0.9975395,0.0004052727,0.0005000667,0.0005549517,0.0005900146,0.0004102361],"domain_scores_gemma":[0.9987378,0.0001031274,0.00009381284,0.0003950719,0.0005172242,0.0001529578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01304782,0.00936424,0.9577814,0.00004148939,0.00003156978,0.00003889564,0.000652677,0.00001364528,0.001698318,0.000003828016,0.00005239265,0.01727374],"study_design_scores_gemma":[0.0409218,0.03801613,0.8970892,0.0001429439,0.000005490062,7.075675e-7,0.0006213405,0.00005114147,0.02288264,0.00001457407,0.00007212604,0.0001818851],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985136,0.00009215774,0.000008973578,0.00001915939,0.00003066277,0.001130165,0.00001455026,0.000002849925,0.0001878812],"genre_scores_gemma":[0.9994266,0.00009117599,0.000137176,0.00000960379,0.00002627481,0.0002008648,0.000024589,0.00002785809,0.00005582482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06069215,"threshold_uncertainty_score":0.4297885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0606253614671827,"score_gpt":0.4430309267504193,"score_spread":0.3824055652832365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}