{"id":"W2150127982","doi":"10.2337/db09-0949","title":"Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid–Induced ER Stress–Mediated β-Cell Death","year":2009,"lang":"en","type":"article","venue":"Diabetes","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Canadian Diabetes Association; American Diabetes Association","keywords":"TXNIP; Unfolded protein response; Apoptosis; Programmed cell death; Biology; Endocrinology; Beta cell; Internal medicine; Endoplasmic reticulum; Cell biology; Chemistry; Biochemistry; Thioredoxin; Insulin; Oxidative stress; Medicine; Islet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001784453,0.0006130169,0.0003861759,0.0001938186,0.0001508777,0.0003138961,0.0002540522,0.0002685719,0.001682502],"category_scores_gemma":[0.0001450694,0.000164927,0.0002652634,0.0001621082,0.0003739514,0.0003411583,0.0002311009,0.0007217735,0.000383228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001982088,"about_ca_system_score_gemma":0.0002879139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002050827,"about_ca_topic_score_gemma":0.0002915198,"domain_scores_codex":[0.9998496,0.00001805134,0.00002307432,0.00004316545,0.00003270421,0.00003339157],"domain_scores_gemma":[0.9997528,0.00002658151,0.00007980215,0.00003984333,0.0000257694,0.00007519467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002969402,0.0000266203,0.0001362873,0.00003272745,0.000006689895,0.00003501012,0.000007393727,0.00001794444,0.9988657,0.00002071053,0.00001158349,0.0005423371],"study_design_scores_gemma":[0.00004717211,0.0006052804,0.002970285,0.00000926207,0.00002481137,0.0002488154,0.00003262435,0.0001980815,0.9948003,0.00002122622,0.001039172,0.000002885314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961785,0.001168534,0.001614708,0.0001082226,0.00003330583,0.00001936327,0.0002861628,0.00006490167,0.0005263379],"genre_scores_gemma":[0.9921106,0.001527202,0.002478112,0.00006836157,0.00002519582,0.00006516217,0.001151161,0.00004487735,0.002529418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001682502,"threshold_uncertainty_score":0.005628467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01523614602534284,"score_gpt":0.2419527249704977,"score_spread":0.2267165789451548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}