{"id":"W2150127982","doi":"10.2337/db09-0949","title":"Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid–Induced ER Stress–Mediated β-Cell Death","year":2009,"lang":"en","type":"article","venue":"Diabetes","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Canadian Diabetes Association; American Diabetes Association","keywords":"TXNIP; Unfolded protein response; Apoptosis; Programmed cell death; Biology; Endocrinology; Beta cell; Internal medicine; Endoplasmic reticulum; Cell biology; Chemistry; Biochemistry; Thioredoxin; Insulin; Oxidative stress; Medicine; Islet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009784667,0.0004063285,0.0004343222,0.00009835319,0.00009143881,0.00004412713,0.000366064,0.0003476051,0.00001951181],"category_scores_gemma":[0.0004388136,0.0003684091,0.0002463382,0.0001887923,0.00009046758,0.00001242379,0.0000975868,0.0001918177,0.00003413807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002064335,"about_ca_system_score_gemma":0.000123102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001102439,"about_ca_topic_score_gemma":0.000002070325,"domain_scores_codex":[0.9978391,0.0001096522,0.0004733691,0.0006272718,0.0003200142,0.0006305766],"domain_scores_gemma":[0.9985175,0.00005026833,0.000273161,0.0006365887,0.0001948242,0.0003277173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008616045,0.0003957239,0.00860582,0.0001027033,0.00006989677,0.00000513349,0.00003287725,0.00005019993,0.9888951,0.000005456567,0.0005641151,0.001186877],"study_design_scores_gemma":[0.001654896,0.0003829674,0.005607809,0.00008744266,0.00004036536,1.581647e-7,0.00004511887,0.0002918904,0.9912098,0.00001600192,0.0002374518,0.0004260889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953173,0.0005626479,0.00002599401,0.0001525461,0.0001620515,0.0005992432,0.0005516221,0.00005433238,0.002574289],"genre_scores_gemma":[0.9961951,0.0002669481,0.0003948064,0.001137781,0.0001852013,0.00008742431,0.00159493,0.00004323848,0.00009452245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002998011,"threshold_uncertainty_score":0.9998768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01523614602534284,"score_gpt":0.2419527249704977,"score_spread":0.2267165789451548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}