{"id":"W2150139517","doi":"10.1681/asn.2009060672","title":"GSK3β Mediates Renal Response to Vasopressin by Modulating Adenylate Cyclase Activity","year":2010,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; American Society of Nephrology","keywords":"Aquaporin 2; Endocrinology; Internal medicine; Nephrogenic diabetes insipidus; Vasopressin; Adenylate kinase; Knockout mouse; GSK-3; Cyclase; Reabsorption; Protein kinase A; GSK3B; Arginine vasopressin receptor 2; Chemistry; Biology; Kinase; Kidney; Medicine; Cell biology; Water channel; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000170052,0.0005512231,0.0002112749,0.0002226793,0.0001732413,0.000382328,0.000137215,0.000171234,0.001686925],"category_scores_gemma":[0.0001661302,0.000167913,0.0002819765,0.0001177691,0.000347424,0.0001568169,0.0002349621,0.0004901308,0.0004469157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003802596,"about_ca_system_score_gemma":0.0004024235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005449748,"about_ca_topic_score_gemma":0.001261184,"domain_scores_codex":[0.99992,0.00001462461,0.000007561245,0.00001572077,0.00001572861,0.00002639023],"domain_scores_gemma":[0.9999071,0.000008544142,0.0000377029,0.000008145525,0.000008515711,0.00002997702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003899259,0.00002277872,0.001429444,0.00009969206,0.00001994574,0.0001246556,0.00002084627,0.0002040315,0.9940804,0.0003104654,0.0002499985,0.003047886],"study_design_scores_gemma":[0.0002530699,0.0004688787,0.03814584,0.00003721602,0.00009431673,0.0006551394,0.00008062815,0.002169216,0.9493292,0.001019565,0.007727543,0.00001945553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791465,0.009602666,0.005383272,0.0006914367,0.0001246089,0.00003335189,0.0007534624,0.0003519806,0.003912621],"genre_scores_gemma":[0.9945756,0.002740915,0.0009120733,0.0000902848,0.00002269546,0.00002564327,0.0003429837,0.00002131076,0.001268531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001686925,"threshold_uncertainty_score":0.005643368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006331347696296632,"score_gpt":0.2488151962561598,"score_spread":0.2424838485598632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}