{"id":"W2150139517","doi":"10.1681/asn.2009060672","title":"GSK3β Mediates Renal Response to Vasopressin by Modulating Adenylate Cyclase Activity","year":2010,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; American Society of Nephrology","keywords":"Aquaporin 2; Endocrinology; Internal medicine; Nephrogenic diabetes insipidus; Vasopressin; Adenylate kinase; Knockout mouse; GSK-3; Cyclase; Reabsorption; Protein kinase A; GSK3B; Arginine vasopressin receptor 2; Chemistry; Biology; Kinase; Kidney; Medicine; Cell biology; Water channel; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004959581,0.000109546,0.000239999,0.00002333144,0.00007677218,0.000006244705,0.0002769266,0.0001087629,0.00001096301],"category_scores_gemma":[0.00006429461,0.00008026075,0.0003133705,0.0001265435,0.0003516771,0.000007318233,0.00005941793,0.0002573776,5.611272e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001001702,"about_ca_system_score_gemma":0.00008251084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001924306,"about_ca_topic_score_gemma":0.00001116261,"domain_scores_codex":[0.9991114,0.0001315234,0.0002663266,0.0001308592,0.000183068,0.0001768012],"domain_scores_gemma":[0.9988484,0.00004996626,0.0006593296,0.0002193468,0.0001367729,0.00008620589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001275373,0.00004610214,0.001265589,0.000003302294,0.00009025478,6.961914e-7,0.0001696747,0.0003568816,0.9804434,8.284186e-7,0.01431084,0.002037029],"study_design_scores_gemma":[0.0006218404,0.0007945767,0.1880751,0.00001037492,0.00005119087,0.00006457549,0.0001146737,0.0003375694,0.7749245,0.00006346461,0.03481041,0.0001316567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929128,0.00005219636,0.001360388,0.00544892,0.0001419299,0.00006047637,0.00001283361,0.000002745961,0.000007677583],"genre_scores_gemma":[0.9955981,0.00003788561,0.002346373,0.001520742,0.0003563768,0.000001600728,0.000003301301,0.00001341219,0.0001222303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2055189,"threshold_uncertainty_score":0.3272938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006331347696296632,"score_gpt":0.2488151962561598,"score_spread":0.2424838485598632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}