{"id":"W2150170782","doi":"10.1038/ng.465","title":"SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas","year":2009,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":952,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Biology; Cancer research; SOX2; Ectopic expression; Esophagus; Oncogene; Cellular differentiation; Transcription factor; Cell; Cell culture; Gene; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002247099,0.0001877525,0.0001926646,0.0006232353,0.0002254768,0.0003724555,0.0001687454,0.0001895135,0.001770756],"category_scores_gemma":[0.0002784899,0.0002036626,0.000145986,0.0003321993,0.0002603226,0.0002137991,0.0002524066,0.0002011487,0.0002717302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002586187,"about_ca_system_score_gemma":0.0002107313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001509754,"about_ca_topic_score_gemma":0.002036782,"domain_scores_codex":[0.999873,0.00001771734,0.00001340105,0.00001813241,0.00005203116,0.000025683],"domain_scores_gemma":[0.9998292,0.00003706621,0.0000303634,0.00001890824,0.00003048475,0.00005396137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004817455,0.00002065023,0.02304403,0.00003455543,0.00002192287,0.001125833,0.00007883187,0.00008619217,0.9719059,0.0003508044,0.00009110222,0.002758503],"study_design_scores_gemma":[0.00006879975,0.0002288527,0.4202235,0.00001254694,0.0001010618,0.008213668,0.000477446,0.001975829,0.5634789,0.0005119753,0.004693127,0.00001424543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969274,0.0007760239,0.0006713397,0.00004463023,0.000009533275,0.000006811319,0.0001267132,0.00002099329,0.001416582],"genre_scores_gemma":[0.9976187,0.0002473999,0.0002795474,0.000009924473,0.000007084697,0.000004948619,0.0001959384,0.000006795389,0.001629619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001770756,"threshold_uncertainty_score":0.005923808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01017174342488764,"score_gpt":0.2744493561528173,"score_spread":0.2642776127279297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}