{"id":"W2150203800","doi":"10.1085/jgp.20028760","title":"Rapid Induction of P/C-type Inactivation Is the Mechanism for Acid-induced K+ Current Inhibition","year":2003,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Biophysics; Conductance; Extracellular; Membrane potential; Potassium channel; Current (fluid); Potassium; Hyperpolarization (physics); Patch clamp; Biochemistry; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003983162,0.00007897839,0.0001101104,0.00004123992,0.00009952364,0.000003607624,0.00007129016,0.00008719026,0.00001652665],"category_scores_gemma":[0.0001151669,0.00004520659,0.00009194786,0.00008995587,0.00003853633,0.000008704276,0.00001359569,0.00009848207,9.251638e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001587608,"about_ca_system_score_gemma":0.0000591956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002475033,"about_ca_topic_score_gemma":6.677473e-7,"domain_scores_codex":[0.9992875,0.0002025241,0.0002518892,0.00007714818,0.00008853152,0.00009235884],"domain_scores_gemma":[0.9989913,0.00001741156,0.0003794128,0.0001284951,0.0004642451,0.00001910941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003434906,0.00003434215,0.000001583287,0.000006597353,0.00003288647,1.372031e-8,0.00009050896,0.0002269857,0.9921365,0.002284838,0.002493719,0.00234856],"study_design_scores_gemma":[0.0005017685,0.0008075369,0.0003513328,0.000006630431,0.00002898025,0.00002118742,0.0001236888,0.0002192524,0.9850133,0.007958629,0.004916023,0.0000516827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903687,0.0002228879,0.007108322,0.0005367112,0.00157371,0.0001499998,0.000002172909,0.000001584398,0.00003594783],"genre_scores_gemma":[0.9982814,0.0003338744,0.0001194579,0.0003153901,0.0008677884,0.000003761533,0.00001819553,0.000008022812,0.00005210166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007912745,"threshold_uncertainty_score":0.1843471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03455894581401243,"score_gpt":0.2770611137180199,"score_spread":0.2425021679040075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}