{"id":"W2150205774","doi":"10.1002/cmdc.200800236","title":"Ground State, Intermediate, and Multivalent Nucleotide Analogue Inhibitors of Cytidine 5′‐Triphosphate Synthase","year":2008,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; University of Waterloo","funders":"","keywords":"Cytidine; Nucleotide; ATP synthase; Nucleotide salvage; Chemistry; Adenosine triphosphate; Biochemistry; Enzyme; Stereochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002544605,0.0002305841,0.0003410979,0.0002341957,0.0002073452,0.0005638553,0.0005084455,0.0002690499,0.001883344],"category_scores_gemma":[0.000278682,0.0001647965,0.0001378687,0.0001590696,0.0001749427,0.0002216443,0.0001602939,0.0006200268,0.0001828828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005047491,"about_ca_system_score_gemma":0.0003378451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001057867,"about_ca_topic_score_gemma":0.001633025,"domain_scores_codex":[0.9998773,0.00002153093,0.00001106855,0.00002049709,0.00002733304,0.0000422819],"domain_scores_gemma":[0.9998711,0.00004747459,0.00002001432,0.00001701311,0.00001101778,0.00003341753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003733397,0.0006168527,0.0004007467,0.0001193991,0.00005712435,0.0001948542,0.00006982308,0.001799917,0.9767855,0.003443307,0.0005147182,0.0122643],"study_design_scores_gemma":[0.0002940694,0.001682856,0.0005860211,0.000007966239,0.00004307194,0.0001736345,0.00001474108,0.004087597,0.9901329,0.0002240615,0.002741834,0.0000112881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925961,0.001338621,0.001268151,0.00007303234,0.0000735937,0.000040617,0.0001468792,0.00009844657,0.004364593],"genre_scores_gemma":[0.9975395,0.0003762449,0.0003994998,0.00001812656,0.00001379414,0.00001149328,0.0001323953,0.00001505864,0.001493778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001883344,"threshold_uncertainty_score":0.006300449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01490067024573157,"score_gpt":0.2478208290761557,"score_spread":0.2329201588304241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}