{"id":"W2150205774","doi":"10.1002/cmdc.200800236","title":"Ground State, Intermediate, and Multivalent Nucleotide Analogue Inhibitors of Cytidine 5′‐Triphosphate Synthase","year":2008,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; University of Waterloo","funders":"","keywords":"Cytidine; Nucleotide; ATP synthase; Nucleotide salvage; Chemistry; Adenosine triphosphate; Biochemistry; Enzyme; Stereochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001462781,0.0002120598,0.0002424397,0.00005541228,0.00006454445,0.000008960362,0.0001982475,0.0001552006,0.00002115642],"category_scores_gemma":[0.0001941622,0.0001922178,0.0001132642,0.0001391389,0.0006015094,0.000006284443,0.0003095973,0.0001611792,0.000007343102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001966812,"about_ca_system_score_gemma":0.00006933891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006916381,"about_ca_topic_score_gemma":0.000008886217,"domain_scores_codex":[0.9986606,0.00003193099,0.0003029047,0.0004362318,0.0002146672,0.000353654],"domain_scores_gemma":[0.9991864,0.00002158712,0.00009673208,0.000328637,0.0001246652,0.000242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001566835,0.0001527878,0.003030673,0.00008842839,0.00006629557,0.00003693608,0.00007372699,0.00000131394,0.9918926,0.000007524725,0.002295395,0.002197634],"study_design_scores_gemma":[0.0009351536,0.000244884,0.004276236,0.00003466805,0.00001100926,0.00004416783,0.00003838547,0.00002050332,0.9913473,0.000036343,0.00279955,0.0002118617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972695,0.001772722,0.0001007714,0.00008439172,0.00006607196,0.0001910536,0.00004057795,0.00001480628,0.0004601835],"genre_scores_gemma":[0.9971833,0.001372817,0.0002613764,0.00009842099,0.0001029435,0.00002063264,0.0001532929,0.00003211363,0.0007751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001985773,"threshold_uncertainty_score":0.7838414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01490067024573157,"score_gpt":0.2478208290761557,"score_spread":0.2329201588304241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}