{"id":"W2150261056","doi":"10.1073/pnas.252093999","title":"An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Origin recognition complex; Cell biology; Immunoprecipitation; Biology; Chromatin; DNA replication; Mutant; Origin of replication; DNA; Chromatin immunoprecipitation; Cell cycle; Molecular biology; Eukaryotic DNA replication; Genetics; Cell; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004005412,0.0000774274,0.00009992301,0.00007214145,0.0000839327,0.00001694004,0.000164714,0.00005713728,0.000008136162],"category_scores_gemma":[0.00004540916,0.00005429984,0.00001855357,0.0001367268,0.0004264783,0.00004524098,0.0000488333,0.00005725849,9.004493e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008540191,"about_ca_system_score_gemma":0.000009342059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007889695,"about_ca_topic_score_gemma":0.000001261513,"domain_scores_codex":[0.9992238,0.000008258822,0.0001686408,0.0002057074,0.0003010887,0.00009246624],"domain_scores_gemma":[0.9995722,0.00001768876,0.0002622243,0.000008886067,0.0001054898,0.00003346911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003247517,0.00002253745,0.003926751,0.0000449718,0.00001298329,1.541771e-8,0.0001549809,0.00001461931,0.993368,0.0005632989,0.00003071802,0.001828685],"study_design_scores_gemma":[0.0003530559,0.0003138953,0.02200672,0.0001002777,0.00001705201,0.00006202894,0.0002056509,0.003166944,0.9627713,0.0107747,0.0001238669,0.000104504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990853,0.00007562768,0.000003382711,0.0003750895,0.000008331872,0.00009914885,0.00001374341,0.000003999648,0.0003353771],"genre_scores_gemma":[0.9952173,0.00007532116,0.004572421,0.00005718293,0.00003871822,0.000004208644,0.000001240089,0.000003990697,0.00002963745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03059666,"threshold_uncertainty_score":0.2214283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04685527422894148,"score_gpt":0.2958133768950215,"score_spread":0.24895810266608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}