{"id":"W2150262988","doi":"10.1074/jbc.m113.458133","title":"Structural Sensitivity of a Prokaryotic Pentameric Ligand-gated Ion Channel to Its Membrane Environment","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research","keywords":"Ligand-gated ion channel; Ion channel; Chemistry; Biophysics; Homology modeling; Nicotinic acetylcholine receptor; Lipid bilayer; Membrane; Biochemistry; Nicotinic agonist; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003193468,0.0002050808,0.0003842131,0.00002098818,0.00003607306,0.00001079155,0.0002076526,0.000212243,0.0001585175],"category_scores_gemma":[0.0003225506,0.0001431869,0.0001870988,0.00008184526,0.00009329557,0.000006794335,0.0001992975,0.0002153437,0.00001704016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003263445,"about_ca_system_score_gemma":0.00004036969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006395294,"about_ca_topic_score_gemma":2.520071e-7,"domain_scores_codex":[0.9986741,0.00009497051,0.0005137118,0.0002569277,0.0002034907,0.0002567925],"domain_scores_gemma":[0.9989915,0.00003470588,0.0004218462,0.0001915807,0.0001555723,0.0002047873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001172335,0.0001212526,0.001410522,0.0000294252,0.00007574871,0.000002586546,0.00002397463,0.0001391512,0.9972581,2.108693e-7,0.00025236,0.0005694641],"study_design_scores_gemma":[0.0005210639,0.0005473485,0.006127259,0.00002637441,0.00002100045,0.0001489375,0.0001027952,0.00008193457,0.9918689,0.000005478641,0.0003806268,0.0001683345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987876,0.0004022611,0.0001187528,0.0002583957,0.00009418984,0.0002279389,0.00001189864,0.000004891582,0.00009411012],"genre_scores_gemma":[0.9987043,0.0002652118,0.0003802828,0.0001017924,0.0003723833,0.000005056509,0.00002203156,0.00001219152,0.0001367444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005389224,"threshold_uncertainty_score":0.5838993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488025492443155,"score_gpt":0.2386233884327963,"score_spread":0.2237431335083648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}