{"id":"W2150267627","doi":"10.1152/ajpgi.00393.2013","title":"The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis","year":2014,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institutes of Health","keywords":"Histone deacetylase 2; HDAC1; Biology; Inflammation; Cell biology; Colitis; Gene expression; Inflammatory bowel disease; Homeostasis; Cancer research; Histone; Immunology; Histone deacetylase; Biochemistry; Gene; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004816633,0.0003098552,0.000533876,0.0001436005,0.0002015223,0.00002761612,0.0003313956,0.00005802302,0.000008925439],"category_scores_gemma":[0.0003492474,0.0002260522,0.0001348411,0.0001235477,0.001998804,0.00001755411,0.0003177742,0.0004527539,0.00000484772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005104757,"about_ca_system_score_gemma":0.0001112972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000105412,"about_ca_topic_score_gemma":0.0000290541,"domain_scores_codex":[0.9972869,0.000966522,0.0005301254,0.0004590095,0.0001911886,0.0005662446],"domain_scores_gemma":[0.9983929,0.0004598726,0.000471425,0.0002743522,0.0001673284,0.0002340807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002617601,0.0001501877,0.001526085,0.00002045927,0.00003139917,0.00002055937,0.000150785,0.00005449659,0.9932809,0.00007905011,0.00005594889,0.002012514],"study_design_scores_gemma":[0.003328193,0.0206058,0.6525534,0.0001919209,0.00004720275,0.003944946,0.001798169,0.0009589249,0.3147653,0.0008196355,0.0004293134,0.0005570863],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998811,0.0006603436,0.0001146008,0.000140381,0.00009608846,0.0001411873,0.00001186313,0.000005962836,0.00001854434],"genre_scores_gemma":[0.9982027,0.0001898227,0.001075557,0.0001132747,0.0002732431,0.00001340854,0.00001136382,0.00002869373,0.00009195798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6785156,"threshold_uncertainty_score":0.921814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005704558774343623,"score_gpt":0.2361670371950798,"score_spread":0.2304624784207362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}