{"id":"W2150272362","doi":"10.1097/01.mjt.0000178767.67857.63","title":"Autoimmune Destruction of Pancreatic β Cells","year":2005,"lang":"en","type":"review","venue":"American Journal of Therapeutics","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":306,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; American Diabetes Association","keywords":"Cytotoxic T cell; Antigen-presenting cell; Interleukin 21; Natural killer T cell; Pancreatic islets; Antigen presentation; Granzyme; Interleukin 12; CD40; T cell; IL-2 receptor; ZAP70; Cell biology; CD8; Immunology; Immune system; Perforin; Biology; Islet; Endocrinology; Insulin; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003360239,0.0006501628,0.0004306283,0.000562087,0.0002974399,0.0007628608,0.0003365947,0.0005061798,0.005628939],"category_scores_gemma":[0.0003344548,0.0001644335,0.0003947293,0.0004186903,0.0002829447,0.00036806,0.0005338788,0.0007863876,0.002683915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002550845,"about_ca_system_score_gemma":0.0002095871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002559815,"about_ca_topic_score_gemma":0.0001272064,"domain_scores_codex":[0.9997414,0.0000490491,0.00002278008,0.00006326623,0.00007078221,0.00005278052],"domain_scores_gemma":[0.9998424,0.00002117228,0.000045684,0.00001861434,0.00002751481,0.00004454851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001062147,0.0002856358,0.01214049,0.00324641,0.0002885592,0.006132734,0.0003602074,0.0002699008,0.6358082,0.004053799,0.02073989,0.315612],"study_design_scores_gemma":[0.0003115709,0.001717649,0.05492773,0.001491342,0.000505731,0.03960484,0.0005036988,0.0007553007,0.2238363,0.005388273,0.6708905,0.00006701888],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4162644,0.4478114,0.01857105,0.002744716,0.003901396,0.0002937142,0.001638672,0.001297105,0.1074776],"genre_scores_gemma":[0.750045,0.191458,0.00600605,0.003626402,0.001803302,0.0003024548,0.001856737,0.0001173715,0.04478466],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005628939,"threshold_uncertainty_score":0.01883072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01608239235914756,"score_gpt":0.2967163956261387,"score_spread":0.2806340032669912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}