{"id":"W2150272362","doi":"10.1097/01.mjt.0000178767.67857.63","title":"Autoimmune Destruction of Pancreatic β Cells","year":2005,"lang":"en","type":"review","venue":"American Journal of Therapeutics","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":306,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; American Diabetes Association","keywords":"Cytotoxic T cell; Antigen-presenting cell; Interleukin 21; Natural killer T cell; Pancreatic islets; Antigen presentation; Granzyme; Interleukin 12; CD40; T cell; IL-2 receptor; ZAP70; Cell biology; CD8; Immunology; Immune system; Perforin; Biology; Islet; Endocrinology; Insulin; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002017006,0.0002242336,0.001088157,0.00009481787,0.00002276049,0.00001220872,0.0003130305,0.0001331624,0.000009618554],"category_scores_gemma":[0.00001285382,0.0001767534,0.0006386228,0.0001857683,0.0001702426,0.000002885512,0.00003346621,0.0002057539,0.000002574421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003099783,"about_ca_system_score_gemma":0.0002399681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004736509,"about_ca_topic_score_gemma":6.983244e-7,"domain_scores_codex":[0.9986889,0.0001572605,0.0006950977,0.0001197625,0.000157201,0.0001817544],"domain_scores_gemma":[0.9975082,0.00003202272,0.002053891,0.0002279702,0.0001315766,0.00004629349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001175153,0.00006280219,0.00001132142,0.0002135033,0.00101051,7.243823e-7,0.00001591749,0.00001416118,0.0009662841,0.00000287922,0.00007695299,0.9976132],"study_design_scores_gemma":[0.000173825,0.0007781675,0.000009113219,0.000888433,0.001396046,0.00003306214,0.00009180749,0.000001834109,0.0003310674,0.00001103668,0.9961052,0.0001803969],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002193014,0.9972625,0.0001147764,0.00001719178,0.0002046133,0.00008443461,0.00001733588,0.000002224973,0.0001039299],"genre_scores_gemma":[0.001355675,0.9968608,0.001302563,0.00007370243,0.0002312,0.000001595259,0.00001810945,0.00004249952,0.0001138696],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9974328,"threshold_uncertainty_score":0.7207793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01608239235914756,"score_gpt":0.2967163956261387,"score_spread":0.2806340032669912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}