{"id":"W2150274550","doi":"10.1034/j.1600-0447.2001.00299.x","title":"CYP2D6 and CYP2C19 genotype‐based dose recommendations for antidepressants:
a first step towards subpopulation‐specific dosages","year":2001,"lang":"en","type":"article","venue":"Acta Psychiatrica Scandinavica","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":423,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"CYP2D6; CYP2C19; Pharmacogenetics; Pharmacology; Dose; Medicine; Tricyclic; Drug; Pharmacokinetics; Therapeutic drug monitoring; Genotype; Cytochrome P450; Internal medicine; Biology; Genetics; Gene; Metabolism","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01059897,0.0006568672,0.001776859,0.001728911,0.0004291586,0.001258009,0.001680528,0.001534697,0.002039049],"category_scores_gemma":[0.03481377,0.0004094045,0.001204193,0.001129824,0.0003061523,0.001175293,0.0004949956,0.002147418,0.0009833768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006745526,"about_ca_system_score_gemma":0.001506048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009611688,"about_ca_topic_score_gemma":0.002346778,"domain_scores_codex":[0.9933261,0.003897077,0.001444161,0.0002471543,0.001016082,0.00006936252],"domain_scores_gemma":[0.9844375,0.008825588,0.001909416,0.001055771,0.003587494,0.0001842415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001947984,0.0004579971,0.07897245,0.004103911,0.001366508,0.0005384246,0.0009632647,0.01178791,0.008915185,0.005777577,0.02945011,0.8557187],"study_design_scores_gemma":[0.003627486,0.01131749,0.4507558,0.009454554,0.006307158,0.01081319,0.002548644,0.0590282,0.03255609,0.05225159,0.3605439,0.00079588],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2747521,0.1235231,0.4954932,0.06034275,0.001816094,0.002204382,0.004457083,0.002388443,0.03502278],"genre_scores_gemma":[0.4355614,0.0163423,0.535925,0.005731093,0.0009304039,0.001225861,0.001958008,0.0002429307,0.002083036],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01059897,"threshold_uncertainty_score":0.0560534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1359243710060618,"score_gpt":0.4378611409673693,"score_spread":0.3019367699613075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}