{"id":"W2150315209","doi":"10.1124/dmd.109.027292","title":"Bioactivation of Minocycline to Reactive Intermediates by Myeloperoxidase, Horseradish Peroxidase, and Hepatic Microsomes: Implications for Minocycline-Induced Lupus and Hepatitis","year":2009,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Adduct; Myeloperoxidase; Reactive intermediate; Minocycline; Horseradish peroxidase; Microsome; Peroxidase; Protonation; Stereochemistry; Iminium; Medicinal chemistry; Enzyme; Biochemistry; Organic chemistry; Ion; Catalysis; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004817698,0.0005201352,0.0002583747,0.0002508931,0.0002840409,0.0003927342,0.0002341318,0.0004021926,0.000968744],"category_scores_gemma":[0.0004163189,0.0001667965,0.0002991562,0.0001568817,0.0003465331,0.0005068883,0.0001673405,0.000362419,0.0002337332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004836676,"about_ca_system_score_gemma":0.0003467544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009301543,"about_ca_topic_score_gemma":0.0008304976,"domain_scores_codex":[0.9998602,0.00006132825,0.00000780062,0.0000144275,0.0000177189,0.00003854572],"domain_scores_gemma":[0.9998106,0.00005562491,0.00005486352,0.00002919395,0.0000235768,0.00002616916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001878987,0.0001131031,0.002105036,0.00009018475,0.00002054826,0.0004157021,0.0001538793,0.0004146177,0.9872954,0.001420345,0.00006066537,0.006031452],"study_design_scores_gemma":[0.00001788369,0.0005243614,0.002028831,0.000004318441,0.00001679767,0.0003493903,0.00005218603,0.0008439352,0.9953989,0.0002185918,0.0005385736,0.000006135793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988653,0.001606354,0.00827579,0.0001810534,0.00002460602,0.00003390718,0.00006265756,0.00005441863,0.001108183],"genre_scores_gemma":[0.9974074,0.0004281014,0.001219802,0.00001847047,0.000008099105,0.00001280063,0.00004363682,0.000006996202,0.0008547865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000968744,"threshold_uncertainty_score":0.003509223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007951497365854815,"score_gpt":0.2599976275179601,"score_spread":0.2520461301521053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}