{"id":"W2150315209","doi":"10.1124/dmd.109.027292","title":"Bioactivation of Minocycline to Reactive Intermediates by Myeloperoxidase, Horseradish Peroxidase, and Hepatic Microsomes: Implications for Minocycline-Induced Lupus and Hepatitis","year":2009,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Adduct; Myeloperoxidase; Reactive intermediate; Minocycline; Horseradish peroxidase; Microsome; Peroxidase; Protonation; Stereochemistry; Iminium; Medicinal chemistry; Enzyme; Biochemistry; Organic chemistry; Ion; Catalysis; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521195,0.0002235867,0.0004680862,0.0001826089,0.0001479458,0.00003326842,0.00004491629,0.00009735439,0.000003014273],"category_scores_gemma":[0.00005203468,0.000177102,0.00006423255,0.0001737014,0.00007550483,0.0002418875,0.00001229447,0.0000942078,4.237235e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002084535,"about_ca_system_score_gemma":0.00001969531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001244246,"about_ca_topic_score_gemma":0.00007125269,"domain_scores_codex":[0.9988623,0.0000323446,0.0003839188,0.0003971892,0.0001127496,0.0002114654],"domain_scores_gemma":[0.999225,0.00009005161,0.0001381188,0.0001743503,0.0001453943,0.0002270895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004554045,0.0002530421,0.01121137,0.0001540442,0.0000471682,0.000001303136,0.001610713,1.258641e-7,0.9561044,0.0005392474,0.000373509,0.02924968],"study_design_scores_gemma":[0.00227945,0.0002731173,0.6499311,0.000213495,0.0004175223,0.00002310698,0.0004871961,0.00005369039,0.3439994,0.001254577,0.0008188244,0.0002485037],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887429,0.001808254,0.002120718,0.005635388,0.0001176519,0.001007732,0.0005070042,0.00003210902,0.00002820457],"genre_scores_gemma":[0.9939241,0.00124542,0.002826866,0.0007637527,0.0000996547,0.00009199813,0.0008695549,0.00001940357,0.0001592848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6387197,"threshold_uncertainty_score":0.7222009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007951497365854815,"score_gpt":0.2599976275179601,"score_spread":0.2520461301521053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}