{"id":"W2150323133","doi":"10.1158/1078-0432.ccr-06-0608","title":"Preclinical Characterization of AEG35156/GEM 640, a Second-Generation Antisense Oligonucleotide Targeting X-Linked Inhibitor of Apoptosis","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aegera Therapeutics (Canada)","funders":"","keywords":"XIAP; Cancer research; Inhibitor of apoptosis; Apoptosis; Docetaxel; Cancer; In vivo; Cancer cell; Medicine; Pharmacology; Biology; Programmed cell death; Internal medicine; Caspase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001891293,0.000119515,0.000309059,0.00008583367,0.00008916088,0.0000187264,0.0001581838,0.0003421915,0.0001499131],"category_scores_gemma":[0.0003896765,0.0001105795,0.0001908771,0.0002393353,0.0002456075,0.00001020668,0.0001405132,0.0002352957,0.000004392439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001965128,"about_ca_system_score_gemma":0.0001881689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001124483,"about_ca_topic_score_gemma":0.0001105717,"domain_scores_codex":[0.9974369,0.0004388262,0.001027001,0.0004548129,0.0003691296,0.0002733414],"domain_scores_gemma":[0.9985356,0.0001035438,0.0003135604,0.0003217968,0.0006419279,0.00008354133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002436841,0.0002087625,0.004931908,0.00007207532,0.00002962399,4.844181e-7,0.00001237906,0.00005732527,0.9854119,0.0001180003,0.001328155,0.007585642],"study_design_scores_gemma":[0.0008152864,0.0004956476,0.04160311,0.00004947812,0.00001711397,5.602372e-7,0.00001209189,0.0009025055,0.9494554,0.00008786664,0.006434875,0.0001260279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978144,0.0003380234,0.0006261689,0.0001752889,0.0004436252,0.000367,0.00006626455,0.000008282841,0.0001609657],"genre_scores_gemma":[0.9948072,0.001021405,0.0005597754,0.00003475062,0.002029582,0.00003020661,0.0005469201,0.00002751201,0.0009425987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03667121,"threshold_uncertainty_score":0.4509303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09553153310765983,"score_gpt":0.418686148353545,"score_spread":0.3231546152458851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}