{"id":"W2150323133","doi":"10.1158/1078-0432.ccr-06-0608","title":"Preclinical Characterization of AEG35156/GEM 640, a Second-Generation Antisense Oligonucleotide Targeting X-Linked Inhibitor of Apoptosis","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aegera Therapeutics (Canada)","funders":"","keywords":"XIAP; Cancer research; Inhibitor of apoptosis; Apoptosis; Docetaxel; Cancer; In vivo; Cancer cell; Medicine; Pharmacology; Biology; Programmed cell death; Internal medicine; Caspase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004192395,0.0007476991,0.0003772763,0.0003055743,0.0001339124,0.0002522411,0.0003241585,0.0003899727,0.001768263],"category_scores_gemma":[0.0002476743,0.000162341,0.0003013774,0.0001624817,0.0002386557,0.0002728262,0.0001202818,0.0007696027,0.0004358364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005341229,"about_ca_system_score_gemma":0.0005940078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000894239,"about_ca_topic_score_gemma":0.001367813,"domain_scores_codex":[0.9998952,0.00002572433,0.000007939366,0.00002291892,0.00002385496,0.00002427329],"domain_scores_gemma":[0.9998471,0.00001823999,0.00004447181,0.00001624498,0.00002370929,0.00005022341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001308882,0.001545377,0.0006613884,0.0001326127,0.00003845303,0.00006913755,0.00004226599,0.001485541,0.983374,0.0001504026,0.0003911339,0.01080089],"study_design_scores_gemma":[0.001522529,0.0835968,0.006184524,0.00002976639,0.000216985,0.000732337,0.00004642349,0.003061779,0.8952547,0.0001075403,0.009228664,0.00001803884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860617,0.002284103,0.005972367,0.0001802593,0.00006211887,0.001158054,0.001315687,0.0001174453,0.002848328],"genre_scores_gemma":[0.9890869,0.002009354,0.004184688,0.00009488171,0.00002011253,0.0004011945,0.001883532,0.00002324895,0.002296074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001768263,"threshold_uncertainty_score":0.005915403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09553153310765983,"score_gpt":0.418686148353545,"score_spread":0.3231546152458851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}