{"id":"W2150325077","doi":"10.4049/jimmunol.171.8.4243","title":"Hemozoin Increases IFN-γ-Inducible Macrophage Nitric Oxide Generation Through Extracellular Signal-Regulated Kinase- and NF-κB-Dependent Pathways","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Malaria Research and Control","field":"Medicine","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; McGill University Health Centre; Centre hospitalier universitaire de Québec","funders":"","keywords":"Hemozoin; Signal transduction; Kinase; Cell biology; MAPK/ERK pathway; Nitric oxide synthase; Extracellular; Biology; Phosphorylation; Protein kinase A; Nitric oxide; Molecular biology; Mitogen-Activated Protein Kinase 3; Biochemistry; Heme; Enzyme; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001460916,0.0001764898,0.0004250246,0.0001769778,0.0001854697,0.00003125178,0.0001751939,0.0001579803,0.0005617904],"category_scores_gemma":[0.0005137334,0.0001122135,0.00009996579,0.0002154681,0.0001628783,0.0001503828,0.00004531625,0.0006562916,0.00002316804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009081919,"about_ca_system_score_gemma":0.0002920514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002184801,"about_ca_topic_score_gemma":0.00001012404,"domain_scores_codex":[0.9977504,0.0008444423,0.0005253201,0.0001475281,0.0003526332,0.0003796893],"domain_scores_gemma":[0.9987131,0.0002324456,0.0003136279,0.0003219233,0.0002978424,0.0001210695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001062531,0.00023508,0.0001790104,0.00001748701,0.0003228915,0.0005244802,0.0001244835,0.00004316284,0.9926153,0.001747535,0.0003096886,0.002818396],"study_design_scores_gemma":[0.008588557,0.001998961,0.008318988,0.00008607875,0.0004524481,0.01032077,0.0009027189,0.0006230976,0.964188,0.002313265,0.001993086,0.0002140791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9559421,0.03951873,0.002716323,0.00104762,0.00007575791,0.000300702,0.000003412831,0.00001320801,0.000382124],"genre_scores_gemma":[0.9958999,0.002332703,0.0005973187,0.0002074888,0.0001463169,0.000005192516,0.000004643175,0.00002198816,0.0007844832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03995774,"threshold_uncertainty_score":0.615121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0249444745548132,"score_gpt":0.2506566008619927,"score_spread":0.2257121263071795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}