{"id":"W2150330627","doi":"10.1210/me.2002-0093","title":"Regulation of Niemann-Pick C1 Gene Expression by the 3′5′-Cyclic Adenosine Monophosphate Pathway in Steroidogenic Cells","year":2003,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"CREB; Biology; CREB1; Transactivation; Chromatin immunoprecipitation; Molecular biology; Promoter; Response element; Protein kinase A; Cyclic adenosine monophosphate; Transfection; Gene expression; Gene; Kinase; Transcription factor; Cell biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001731542,0.0003217416,0.0003190487,0.0004223834,0.0003450763,0.0003575566,0.0002146465,0.0002239384,0.0009442236],"category_scores_gemma":[0.0001377953,0.0001802504,0.0002872627,0.0003110212,0.0003403852,0.0001752459,0.0002675211,0.000565152,0.0005348292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006781268,"about_ca_system_score_gemma":0.0003639369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002046437,"about_ca_topic_score_gemma":0.002612087,"domain_scores_codex":[0.9997867,0.00003304252,0.00001987751,0.00004588702,0.00006024573,0.00005435205],"domain_scores_gemma":[0.9998627,0.0000262332,0.00003123924,0.00001955267,0.00002173531,0.00003861716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008879257,0.00001822539,0.0001009828,0.00004139162,0.000002782088,0.0000522107,0.00002510093,0.0000611487,0.9986676,0.0001502416,0.00003242121,0.0007592296],"study_design_scores_gemma":[0.0000184029,0.00007801541,0.005385528,0.000008222261,0.000008246779,0.0001807104,0.00003900709,0.001061023,0.9889009,0.00008323964,0.00422571,0.00001093015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988315,0.0033557,0.004409304,0.0001385116,0.00005616081,0.00007943847,0.001316944,0.0001316612,0.002197332],"genre_scores_gemma":[0.9828008,0.002294726,0.007219085,0.00005987943,0.00001730069,0.0001701548,0.00177482,0.00003563105,0.005627449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002046437,"threshold_uncertainty_score":0.004920125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329673010017625,"score_gpt":0.2583582034379747,"score_spread":0.2450614733377985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}