{"id":"W2150345124","doi":"10.1007/978-0-387-73657-0_95","title":"Stereoselective Synthesis 0f (3S)- and (3R)-3-Hydroxy-3-(2,6-Dimethyl-4-Hydroxyphenyl)Propanoic Acid and its Incorporation into a Cyclic Enkephalin Analogue","year":2009,"lang":"en","type":"article","venue":"Advances in experimental medicine and biology","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Propanoic acid; Chemistry; Stereochemistry; Agonist; Dermorphin; Antagonist; Enkephalin; Opioid peptide; Peptide; Stereoselectivity; Cyclic peptide; Opioid antagonist; Isopropyl; Opioid; Receptor; Medicinal chemistry; Biochemistry; (+)-Naloxone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002447001,0.0003399418,0.0002324383,0.0001759949,0.0001919041,0.0002478498,0.0004529291,0.000371686,0.001634939],"category_scores_gemma":[0.0001691296,0.0001467086,0.0002435724,0.0001646344,0.0001941324,0.000256344,0.000248753,0.0003657301,0.0005813077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003952395,"about_ca_system_score_gemma":0.0005288084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001214596,"about_ca_topic_score_gemma":0.00144275,"domain_scores_codex":[0.9998585,0.00001929744,0.00001279272,0.00002640376,0.00003056966,0.00005257018],"domain_scores_gemma":[0.9998906,0.00001434369,0.00002760979,0.00001984547,0.00001990321,0.00002765654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000171876,0.00002858244,0.00005718078,0.00003245973,0.000006294563,0.0001482042,0.00003824964,0.0002881196,0.9945372,0.0008012082,0.00007259256,0.003818022],"study_design_scores_gemma":[0.00002094579,0.0001985705,0.0002854394,0.000002020643,0.000006750678,0.0001645576,0.00001153477,0.0003110652,0.9958071,0.00006205637,0.00312189,0.000008216417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.967446,0.001182675,0.01707065,0.0001559839,0.0001179635,0.0001660202,0.00112607,0.000163732,0.01257087],"genre_scores_gemma":[0.9797013,0.000643611,0.01199031,0.00004863127,0.00001926278,0.00006548761,0.0005989989,0.0000350177,0.006897359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001634939,"threshold_uncertainty_score":0.005469382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02338393526905673,"score_gpt":0.3466183822775049,"score_spread":0.3232344470084481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}