{"id":"W2150345124","doi":"10.1007/978-0-387-73657-0_95","title":"Stereoselective Synthesis 0f (3S)- and (3R)-3-Hydroxy-3-(2,6-Dimethyl-4-Hydroxyphenyl)Propanoic Acid and its Incorporation into a Cyclic Enkephalin Analogue","year":2009,"lang":"en","type":"article","venue":"Advances in experimental medicine and biology","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Propanoic acid; Chemistry; Stereochemistry; Agonist; Dermorphin; Antagonist; Enkephalin; Opioid peptide; Peptide; Stereoselectivity; Cyclic peptide; Opioid antagonist; Isopropyl; Opioid; Receptor; Medicinal chemistry; Biochemistry; (+)-Naloxone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003167089,0.0003543209,0.0006014809,0.000119584,0.0001055138,0.00001166705,0.000142288,0.0002511333,0.0001626596],"category_scores_gemma":[0.0005433704,0.0002903395,0.00002612919,0.00020928,0.000490538,0.000213,0.0001041554,0.0002486518,0.000001426861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009869239,"about_ca_system_score_gemma":0.00002546014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006837118,"about_ca_topic_score_gemma":0.00002558361,"domain_scores_codex":[0.9982265,0.0001352547,0.0004715783,0.0007225709,0.0001132775,0.0003307915],"domain_scores_gemma":[0.9989243,0.0004706397,0.0002034904,0.0002153485,0.00002837848,0.0001578428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001175984,0.00009192291,0.002173689,0.00005697363,0.0000219479,0.0000103176,0.001125858,2.364209e-7,0.9377374,0.0002309423,0.000003720591,0.05842941],"study_design_scores_gemma":[0.001165688,0.0004552202,0.0002914191,0.0001739991,0.00003738322,0.0001403297,0.002109074,0.0001583236,0.9895293,0.004666763,0.0009624955,0.0003100467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9313966,0.0655587,0.0001051182,0.0006746146,0.00008864039,0.0001461059,0.000008734518,0.00004905364,0.001972413],"genre_scores_gemma":[0.9936382,0.003381932,0.002335136,0.0002819505,0.0002347465,0.00005125376,0.00002911679,0.00001900124,0.00002868069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06224156,"threshold_uncertainty_score":0.9999549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02338393526905673,"score_gpt":0.3466183822775049,"score_spread":0.3232344470084481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}