{"id":"W2150399202","doi":"10.1128/jvi.01659-08","title":"MAVS Dimer Is a Crucial Signaling Component of Innate Immunity and the Target of Hepatitis C Virus NS3/4A Protease","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Saint-Luc; Institute for Research in Immunology and Cancer","funders":"Centre National de la Recherche Scientifique; Canadian Liver Foundation; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Biology; Innate immune system; Cell biology; NS3; Signal transduction; Transmembrane protein; Virology; Hepatitis C virus; Virus; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001323128,0.0003250117,0.0003006857,0.000181626,0.0003073162,0.0003368783,0.0002051402,0.0003358494,0.001055012],"category_scores_gemma":[0.0001748695,0.0001475382,0.0002406993,0.0001624987,0.0002152897,0.0002514446,0.0002078833,0.000372168,0.0005834194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002967295,"about_ca_system_score_gemma":0.0002132583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004015693,"about_ca_topic_score_gemma":0.0003473866,"domain_scores_codex":[0.9998556,0.00003713481,0.000007636761,0.00003198803,0.00005037553,0.00001719809],"domain_scores_gemma":[0.9999287,0.0000121919,0.00002644584,0.000006700036,0.00001183738,0.00001409909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001657218,0.00002204084,0.001199,0.00006810144,0.00001743275,0.0001216555,0.00002129543,0.0005850939,0.9934099,0.000660421,0.0001033535,0.003625967],"study_design_scores_gemma":[0.00002883298,0.0002521432,0.01124629,0.00001424671,0.00004568142,0.001345241,0.0001280618,0.01234095,0.9642844,0.001587425,0.008702979,0.00002375458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980377,0.005811707,0.01140508,0.0002023381,0.00003860704,0.00002404926,0.0002132483,0.0001234651,0.001804759],"genre_scores_gemma":[0.9946945,0.000690462,0.002938001,0.00003418796,0.00000947044,0.000008379613,0.0005039464,0.00001260088,0.001108427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001055012,"threshold_uncertainty_score":0.00352931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134129867105525,"score_gpt":0.2349832031415208,"score_spread":0.2215702164309683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}