{"id":"W2150466650","doi":"10.1128/jvi.00383-15","title":"Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Harvard University Center for AIDS Research","keywords":"Virology; Biology; Immunogen; Immunogenicity; Epitope; Antibody; HIV vaccine; ELISPOT; Antigen; Vaccination; CD8; Immunology; Vaccine trial; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002367061,0.0003102838,0.0001764841,0.0001639358,0.0001240627,0.0001778206,0.0001074285,0.0003303363,0.0006080727],"category_scores_gemma":[0.0002853685,0.00008783891,0.0001807099,0.0000421076,0.0002291477,0.0001655877,0.00008664709,0.0003421815,0.0001410221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002184809,"about_ca_system_score_gemma":0.0001199713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007927257,"about_ca_topic_score_gemma":0.0006304784,"domain_scores_codex":[0.9999115,0.00001747126,0.000004305931,0.00002095145,0.00001670569,0.00002898895],"domain_scores_gemma":[0.9998622,0.00003036823,0.00002462676,0.0000137123,0.00002905943,0.00003991204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002266884,0.00038519,0.00459411,0.00006633859,0.00003813762,0.0001076169,0.0001709355,0.0001502532,0.9881493,0.0000706651,0.00007835703,0.003922174],"study_design_scores_gemma":[0.0004353634,0.07298277,0.2143457,0.00005845677,0.0003261405,0.001816925,0.0005579852,0.00298966,0.7026926,0.0002503035,0.00351889,0.00002528803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999663,0.0001081889,0.00006677728,0.000009112503,0.00000308798,0.000004392924,0.00001596859,0.000002994651,0.0001265234],"genre_scores_gemma":[0.9992269,0.00009592494,0.0001451587,0.00003118691,0.000005964718,0.00001174404,0.00009086652,0.000003017996,0.0003892646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007927257,"threshold_uncertainty_score":0.002034247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0322156343155701,"score_gpt":0.3100990008414544,"score_spread":0.2778833665258843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}