{"id":"W2150472993","doi":"10.1172/jci57256","title":"An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":824,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Simon Fraser University","funders":"Canadian Institutes of Health Research; Universidade Federal do Rio de Janeiro; National Institute on Aging; Instituto Nacional de Ciência e Tecnologia de Neurociência Translacional; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; T.L.L Temple Foundation; National Institutes of Health; John Simon Guggenheim Memorial Foundation; American Health Assistance Foundation; Alzheimer's Association","keywords":"Hippocampal formation; Insulin receptor; Phosphorylation; Endocrinology; Insulin resistance; Insulin; Diabetes mellitus; Internal medicine; Signal transduction; Hippocampus; Neuroscience; Medicine; Chemistry; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000197164,0.0009371999,0.0004386473,0.0007407385,0.0002853829,0.0003428178,0.0005121939,0.0005995296,0.002305709],"category_scores_gemma":[0.0001113818,0.0003284239,0.0005093334,0.0002839713,0.0002745578,0.0003358963,0.0001748875,0.001582675,0.0005921538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002779647,"about_ca_system_score_gemma":0.0003309342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005909134,"about_ca_topic_score_gemma":0.0008439911,"domain_scores_codex":[0.9998438,0.0000148552,0.00002337604,0.00003992475,0.00003290387,0.00004508789],"domain_scores_gemma":[0.9998295,0.00001677254,0.00004686553,0.00002457636,0.00002221016,0.00006005207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001040925,0.0005570853,0.000187282,0.00007014826,0.00002626622,0.00007563167,0.00002221806,0.00004708095,0.9955449,0.0001089834,0.00008661056,0.002232933],"study_design_scores_gemma":[0.0002448626,0.003195086,0.006071066,0.00003356702,0.00005969651,0.0003016305,0.00002970212,0.0006608671,0.986334,0.0001401686,0.002917017,0.00001224551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921795,0.002123547,0.001925817,0.0002198823,0.000134043,0.00007471698,0.0009667759,0.000276961,0.002098823],"genre_scores_gemma":[0.9812262,0.003454365,0.004144695,0.0002547642,0.00004780399,0.0002102953,0.002666757,0.00006587287,0.007929164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002305709,"threshold_uncertainty_score":0.007713377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09846863438673782,"score_gpt":0.3896535907076207,"score_spread":0.2911849563208829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}