{"id":"W2150487989","doi":"10.1128/aac.49.7.2648-2656.2005","title":"The L74V Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Counteracts Enhanced Excision of Zidovudine Monophosphate Associated with Thymidine Analog Resistance Mutations","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Center for AIDS Research, University of Washington; U.S. Public Health Service; McGill University","keywords":"Zidovudine; Primer (cosmetics); Didanosine; Biology; Reverse transcriptase; Nucleotidyltransferase; Virology; Lamivudine; Mutation; Molecular biology; Virus; Genetics; Chemistry; RNA; Viral disease; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001654603,0.0001590616,0.0002444028,0.00007889377,0.0001982467,0.00002291448,0.00006069333,0.00005229455,0.00007231643],"category_scores_gemma":[0.00001826676,0.0001063405,0.00004074863,0.0003310911,0.00009226653,0.000105273,0.000005959012,0.00008684127,0.000003733259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009325078,"about_ca_system_score_gemma":0.00006062898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005653619,"about_ca_topic_score_gemma":0.0003992124,"domain_scores_codex":[0.9990626,0.00003002602,0.0003391018,0.0002122104,0.0001607871,0.0001953059],"domain_scores_gemma":[0.9995021,0.00003696965,0.0001599788,0.0001417172,0.0001149548,0.00004427202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005326615,0.003865977,0.02813737,0.0001404346,0.00092663,0.0001730946,0.01699435,0.0002506128,0.9106483,0.0001679877,0.01841523,0.01495343],"study_design_scores_gemma":[0.02657268,0.0008080545,0.3079011,0.0014357,0.0003266713,0.00002614645,0.0006776673,0.0005231429,0.6285204,0.0001417952,0.0323738,0.0006928548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952269,0.0002211111,0.00005973531,0.003726629,0.00003773339,0.0003852878,0.00001909413,0.00001756725,0.0003059094],"genre_scores_gemma":[0.9928092,0.001826351,0.000308037,0.0007787546,0.00001409236,0.000008185719,0.0001827636,0.00001864718,0.004053904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2821279,"threshold_uncertainty_score":0.4336439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049035867721429,"score_gpt":0.2623900050585961,"score_spread":0.2518996463813818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}