{"id":"W2150487989","doi":"10.1128/aac.49.7.2648-2656.2005","title":"The L74V Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Counteracts Enhanced Excision of Zidovudine Monophosphate Associated with Thymidine Analog Resistance Mutations","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Center for AIDS Research, University of Washington; U.S. Public Health Service; McGill University","keywords":"Zidovudine; Primer (cosmetics); Didanosine; Biology; Reverse transcriptase; Nucleotidyltransferase; Virology; Lamivudine; Mutation; Molecular biology; Virus; Genetics; Chemistry; RNA; Viral disease; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002073692,0.0004175,0.0003532734,0.0002876044,0.0001492088,0.0003044347,0.0004273745,0.0003940751,0.000983729],"category_scores_gemma":[0.0003350277,0.0002187055,0.0003054488,0.0001504833,0.0003044095,0.0001262655,0.0001864998,0.0004422699,0.00031958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003588873,"about_ca_system_score_gemma":0.0002821925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007202043,"about_ca_topic_score_gemma":0.001048831,"domain_scores_codex":[0.9996707,0.00009010227,0.00003864478,0.00004483424,0.00007631553,0.00007942617],"domain_scores_gemma":[0.9998091,0.00005053447,0.00005973167,0.00002472507,0.00001607017,0.00003990384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001006488,0.00007583755,0.0002264059,0.00002204594,0.000009267877,0.00005674491,0.00001219317,0.000115581,0.9976535,0.0001062557,0.00002894564,0.001592478],"study_design_scores_gemma":[0.00004621619,0.001148293,0.002374521,0.000006933305,0.00002219648,0.0002553322,0.00001702389,0.001071519,0.9935572,0.00002717132,0.001466512,0.000007137548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986508,0.0002508987,0.0005132243,0.00002713994,0.00001657258,0.00002139126,0.0000550131,0.00003988335,0.0004251705],"genre_scores_gemma":[0.996695,0.0002199509,0.001620765,0.00002720242,0.00001519618,0.00002501117,0.0002322925,0.00002473941,0.001139772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000983729,"threshold_uncertainty_score":0.003290832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049035867721429,"score_gpt":0.2623900050585961,"score_spread":0.2518996463813818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}