{"id":"W2150491582","doi":"10.1080/15257770008033850","title":"Syntheses of 1-[(2-Hydroxyethoxy)methyl]- and 1-[(1,3-Dihydroxy-2-Propoxy)methyl]- Derivatives of 5-Substituted-2,4-difluorobenzene: Unnatural Acyclo Thymidine Mimics for Evaluation as Anticancer and Antiviral Agents","year":2000,"lang":"en","type":"article","venue":"Nucleosides Nucleotides & Nucleic Acids","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Herpes simplex virus; Stereochemistry; Cytotoxicity; Chemistry; Broad spectrum; Thymidine; Human immunodeficiency virus (HIV); Virus; Combinatorial chemistry; In vitro; Virology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009775205,0.0007318188,0.001429663,0.0004246227,0.0003025083,0.00007364499,0.0002771792,0.0003346701,0.0008729207],"category_scores_gemma":[0.0008570357,0.0006333551,0.0003091095,0.0005670171,0.001042753,0.0006396233,0.0001508224,0.0003095071,0.00002756385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001513266,"about_ca_system_score_gemma":0.0002329467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001354369,"about_ca_topic_score_gemma":0.00002447454,"domain_scores_codex":[0.9959619,0.000224046,0.001182918,0.0009715224,0.0009454918,0.0007141315],"domain_scores_gemma":[0.9974316,0.0006264512,0.0004915199,0.0006347465,0.0005055603,0.000310121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004215928,0.001776413,0.09398855,0.002067511,0.002861927,0.00006588452,0.007955464,0.0001168286,0.4623417,0.003942581,0.001225745,0.4194415],"study_design_scores_gemma":[0.0178141,0.002431645,0.2180587,0.003844054,0.004826251,0.000227461,0.003244625,0.02706146,0.701899,0.005646166,0.01269914,0.002247413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906147,0.002294975,0.00005555993,0.001338424,0.0001544625,0.002171474,0.0001037108,0.0001215035,0.003145208],"genre_scores_gemma":[0.9738919,0.002396654,0.02237827,0.0002299961,0.0001130549,0.00009211912,0.0000895436,0.0001404697,0.0006679731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.417194,"threshold_uncertainty_score":0.9996118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02081815171662714,"score_gpt":0.3045720713108172,"score_spread":0.2837539195941901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}