{"id":"W2150491582","doi":"10.1080/15257770008033850","title":"Syntheses of 1-[(2-Hydroxyethoxy)methyl]- and 1-[(1,3-Dihydroxy-2-Propoxy)methyl]- Derivatives of 5-Substituted-2,4-difluorobenzene: Unnatural Acyclo Thymidine Mimics for Evaluation as Anticancer and Antiviral Agents","year":2000,"lang":"en","type":"article","venue":"Nucleosides Nucleotides & Nucleic Acids","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Herpes simplex virus; Stereochemistry; Cytotoxicity; Chemistry; Broad spectrum; Thymidine; Human immunodeficiency virus (HIV); Virus; Combinatorial chemistry; In vitro; Virology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000151931,0.0003252172,0.0003032572,0.000150963,0.0001458606,0.0001601364,0.0003921051,0.0003224611,0.001689561],"category_scores_gemma":[0.0001323484,0.0001490677,0.0001467378,0.0002156542,0.0001294086,0.0002033106,0.0001495867,0.0003065279,0.000663518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002743843,"about_ca_system_score_gemma":0.0003753117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006098511,"about_ca_topic_score_gemma":0.001725913,"domain_scores_codex":[0.9998894,0.00001887957,0.00001152934,0.00002097473,0.00002851103,0.0000307441],"domain_scores_gemma":[0.9998989,0.000008560954,0.00002882214,0.000009548641,0.00001751963,0.00003660365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001249152,0.00005782552,0.0001082505,0.0001258288,0.000005898861,0.00009238703,0.0000437526,0.0004947105,0.9938557,0.000342084,0.000083041,0.004665598],"study_design_scores_gemma":[0.00005597693,0.001196458,0.001127283,0.00001720261,0.00002268416,0.0004175056,0.00002908235,0.0007159004,0.9845737,0.00006244308,0.01175986,0.00002187752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9572992,0.008450709,0.02205257,0.0001307499,0.0001247309,0.0003346848,0.001202568,0.0002453157,0.01015946],"genre_scores_gemma":[0.9713386,0.004723021,0.01725018,0.00008282855,0.00002295201,0.0001667644,0.001077447,0.0000373964,0.00530085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001689561,"threshold_uncertainty_score":0.00565213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02081815171662714,"score_gpt":0.3045720713108172,"score_spread":0.2837539195941901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}