{"id":"W2150494811","doi":"10.1161/01.res.0000147557.75257.ff","title":"Silent Information Regulator 2α, a Longevity Factor and Class III Histone Deacetylase, Is an Essential Endogenous Apoptosis Inhibitor in Cardiac Myocytes","year":2004,"lang":"en","type":"article","venue":"Circulation Research","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":302,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"National Heart, Lung, and Blood Institute; Canada Research Chairs; American Heart Association","keywords":"Trichostatin A; Myocyte; Histone deacetylase; Apoptosis; Biology; Programmed cell death; Cardiac myocyte; Histone deacetylase inhibitor; Cell biology; Molecular biology; Histone; Endocrinology; Internal medicine; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001474887,0.0005443676,0.0003553398,0.0001932871,0.0001446793,0.000192924,0.0002633119,0.0001851705,0.0007024934],"category_scores_gemma":[0.00009145867,0.0001825415,0.0003523291,0.0001321811,0.0001429421,0.0001409137,0.0001578513,0.0003660526,0.000384063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000273131,"about_ca_system_score_gemma":0.0001904473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003941718,"about_ca_topic_score_gemma":0.0006522664,"domain_scores_codex":[0.9998965,0.00001288182,0.00001202329,0.00002451805,0.00003673704,0.00001731528],"domain_scores_gemma":[0.9999319,0.0000072585,0.0000234491,0.000008120193,0.00001046006,0.00001872391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007964628,0.000009022097,0.0001468739,0.00002495642,0.00000715314,0.00004316184,0.000003622433,0.00002556818,0.9987054,0.00002808303,0.00004600162,0.0008806124],"study_design_scores_gemma":[0.00003872813,0.0003238522,0.003921912,0.00000500823,0.00002736356,0.0004614819,0.000009393513,0.0006793223,0.9916483,0.00002485379,0.002855906,0.000003797354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9646579,0.01602393,0.01480092,0.0001983298,0.0001558182,0.00007118953,0.001155548,0.0003895464,0.002546855],"genre_scores_gemma":[0.9813555,0.004825105,0.005949764,0.0001060629,0.00004201111,0.00008939041,0.003189664,0.00005125814,0.004391191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007024934,"threshold_uncertainty_score":0.002350092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06428418946289935,"score_gpt":0.3570840162838998,"score_spread":0.2927998268210005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}