{"id":"W2150494811","doi":"10.1161/01.res.0000147557.75257.ff","title":"Silent Information Regulator 2α, a Longevity Factor and Class III Histone Deacetylase, Is an Essential Endogenous Apoptosis Inhibitor in Cardiac Myocytes","year":2004,"lang":"en","type":"article","venue":"Circulation Research","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":302,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"National Heart, Lung, and Blood Institute; Canada Research Chairs; American Heart Association","keywords":"Trichostatin A; Myocyte; Histone deacetylase; Apoptosis; Biology; Programmed cell death; Cardiac myocyte; Histone deacetylase inhibitor; Cell biology; Molecular biology; Histone; Endocrinology; Internal medicine; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000962074,0.0001818606,0.0004094382,0.0006496701,0.0002401202,0.00008192014,0.000088097,0.0002406842,0.0001139821],"category_scores_gemma":[0.0002564196,0.0001599787,0.00008679108,0.0006162787,0.0002615734,0.0005435706,0.00006803944,0.0005425384,0.00003096366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006991229,"about_ca_system_score_gemma":0.0004137159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001468434,"about_ca_topic_score_gemma":0.00004575733,"domain_scores_codex":[0.9973475,0.0001795583,0.0004879665,0.0003491546,0.001169572,0.0004663034],"domain_scores_gemma":[0.9985647,0.00009357685,0.00008740974,0.0004247121,0.0004738148,0.000355843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002076569,0.001591455,0.1639904,0.00143355,0.000375466,0.00009685184,0.03353153,0.002110119,0.7313402,0.001260756,0.002007531,0.06018559],"study_design_scores_gemma":[0.01339184,0.001167135,0.8044151,0.0005233092,0.0001144087,0.00007106535,0.003357788,0.004774879,0.1688423,0.0002918763,0.002525591,0.0005246779],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956768,0.0008741295,0.0001690519,0.001477767,0.0002888278,0.001105243,0.00002301709,0.00005068009,0.0003344455],"genre_scores_gemma":[0.9986327,0.0003051004,0.000119775,0.0001850056,0.0004696263,0.00006650203,0.0001475733,0.00002146472,0.00005226216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6404247,"threshold_uncertainty_score":0.6523743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06428418946289935,"score_gpt":0.3570840162838998,"score_spread":0.2927998268210005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}