{"id":"W2150509483","doi":"10.1371/journal.pone.0135988","title":"G Protein-Coupled Estrogen Receptor 1 Mediates Acute Estrogen-Induced Cardioprotection via MEK/ERK/GSK-3β Pathway after Ischemia/Reperfusion","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Vetenskapsrådet; Max and Minnie Tomerlin Voelcker Fund; University of California, Los Angeles; American Heart Association","keywords":"Cardioprotection; Estrogen receptor; Mitochondrial permeability transition pore; Protein kinase B; Estrogen; Endocrinology; Phosphorylation; Internal medicine; Estrogen receptor beta; Estrogen receptor alpha; MAPK/ERK pathway; Chemistry; PI3K/AKT/mTOR pathway; Reperfusion injury; Biology; Cell biology; Medicine; Signal transduction; Ischemia; Apoptosis; Biochemistry; Programmed cell death","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006105608,0.0005415534,0.00105161,0.0002036374,0.0001560531,0.00005041663,0.0001691822,0.0006261703,0.0002891763],"category_scores_gemma":[0.0003552347,0.0004479491,0.0004742722,0.0004562224,0.00009057912,0.0002301365,0.0002306745,0.0007613965,0.0005984053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004277666,"about_ca_system_score_gemma":0.0004314363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000156409,"about_ca_topic_score_gemma":0.000003647846,"domain_scores_codex":[0.9961917,0.0001074831,0.000623936,0.0008643543,0.001520782,0.0006917652],"domain_scores_gemma":[0.9973286,0.00003427869,0.0002359946,0.0009578545,0.0006769344,0.0007663023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001562263,0.0009023329,0.003394133,0.0001930017,0.0009406609,0.0001321777,0.0004417067,9.523751e-7,0.9908483,0.000004795561,0.0001682867,0.001411369],"study_design_scores_gemma":[0.003169287,0.0008601726,0.00006235776,0.0005598455,0.00109447,0.000156467,0.0001238275,0.0004347647,0.9922746,0.00002323212,0.0007409306,0.0005000857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934629,0.001168167,0.00007442177,0.0007406184,0.0003249749,0.002749624,0.00003078127,0.0004295723,0.001018897],"genre_scores_gemma":[0.9900255,0.0001103894,0.004517491,0.0001387272,0.001793698,0.00118498,0.0002248964,0.0001431635,0.001861142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004443069,"threshold_uncertainty_score":0.9997972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02611782058462676,"score_gpt":0.2269040260017043,"score_spread":0.2007862054170776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}