{"id":"W2150509483","doi":"10.1371/journal.pone.0135988","title":"G Protein-Coupled Estrogen Receptor 1 Mediates Acute Estrogen-Induced Cardioprotection via MEK/ERK/GSK-3β Pathway after Ischemia/Reperfusion","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Vetenskapsrådet; Max and Minnie Tomerlin Voelcker Fund; University of California, Los Angeles; American Heart Association","keywords":"Cardioprotection; Estrogen receptor; Mitochondrial permeability transition pore; Protein kinase B; Estrogen; Endocrinology; Phosphorylation; Internal medicine; Estrogen receptor beta; Estrogen receptor alpha; MAPK/ERK pathway; Chemistry; PI3K/AKT/mTOR pathway; Reperfusion injury; Biology; Cell biology; Medicine; Signal transduction; Ischemia; Apoptosis; Biochemistry; Programmed cell death","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001749504,0.0004223319,0.0003642284,0.0002027916,0.0001236706,0.0002164819,0.0001448831,0.0001718613,0.00127142],"category_scores_gemma":[0.00008306021,0.0001816248,0.0004339904,0.000119471,0.0001809684,0.0001783215,0.0001877419,0.0006018308,0.0003420181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001688999,"about_ca_system_score_gemma":0.0002344946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00030009,"about_ca_topic_score_gemma":0.0006244123,"domain_scores_codex":[0.9999233,0.000008417383,0.000007030545,0.00001514914,0.00001389651,0.00003214893],"domain_scores_gemma":[0.999962,0.000002992648,0.00001467188,0.000003936258,0.000004314949,0.00001219048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001268007,0.0000961437,0.0003501142,0.0002008519,0.00002511289,0.0001271511,0.00003459526,0.0001073232,0.99503,0.0001412517,0.000147937,0.002471419],"study_design_scores_gemma":[0.0002351436,0.001220753,0.03685013,0.0000434276,0.0001015186,0.0004537273,0.00006754449,0.001129453,0.9566341,0.0002643523,0.002986807,0.00001293197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915326,0.004520383,0.001166614,0.0001975576,0.00006452369,0.0000283312,0.0006019557,0.0001419649,0.001745953],"genre_scores_gemma":[0.9910363,0.003563838,0.001145002,0.00009337344,0.00002960529,0.00007085534,0.0008380285,0.00001824397,0.003204684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00127142,"threshold_uncertainty_score":0.004253328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02611782058462676,"score_gpt":0.2269040260017043,"score_spread":0.2007862054170776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}