{"id":"W2150512766","doi":"10.1186/s40064-015-1230-1","title":"Blockade of the acute activation of mTOR complex 1 decreases hypertrophy development in rats with severe aortic valve regurgitation","year":2015,"lang":"en","type":"article","venue":"SpringerPlus","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Canadian Institutes of Health Research; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Heart and Stroke Foundation of Canada","keywords":"Regurgitation (circulation); Medicine; Blockade; Cardiology; Muscle hypertrophy; Aortic valve replacement; Internal medicine; PI3K/AKT/mTOR pathway; Signal transduction; Stenosis; Cell biology; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005424026,0.0001031289,0.0002375659,0.00007242787,0.00002165933,0.000004126132,0.00004648893,0.00002942587,0.000009547165],"category_scores_gemma":[0.00006595203,0.0000666705,0.0001790542,0.000214988,0.00004254204,0.00004903298,0.00003234407,0.00004402319,0.000002761562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001597385,"about_ca_system_score_gemma":0.0003527449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001387637,"about_ca_topic_score_gemma":0.000008735502,"domain_scores_codex":[0.9991905,0.00002722528,0.0002131629,0.0001356875,0.000319649,0.000113768],"domain_scores_gemma":[0.9993618,0.00002863697,0.0001387125,0.00021432,0.0001697525,0.00008680583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001719296,0.0006264393,0.9769248,0.0001357989,0.001256005,0.000008008796,0.001155877,0.0002955718,0.01174858,0.00006576741,0.00009316773,0.005970673],"study_design_scores_gemma":[0.002397652,0.0001464014,0.9671967,0.0002455341,0.0003769674,0.000007373992,0.0002008913,0.00006871659,0.02916094,0.00003126489,0.00009453079,0.00007300491],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988,0.00008142174,0.00002228156,0.00008568705,0.00004196517,0.0003932016,0.000007049261,0.0000108371,0.000557498],"genre_scores_gemma":[0.9986869,0.000005947843,0.001118254,0.00003879624,0.00001974744,0.00002477505,0.00002931519,0.00001286988,0.00006337885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01741235,"threshold_uncertainty_score":0.2718744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02741228366517159,"score_gpt":0.3010201523010438,"score_spread":0.2736078686358723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}