{"id":"W2150513485","doi":"10.1016/j.braindev.2011.08.003","title":"Pyruvate dehydrogenase deficiency and epilepsy","year":2011,"lang":"en","type":"review","venue":"Brain and Development","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; Western University","funders":"","keywords":"Pyruvate dehydrogenase complex; Ketogenic diet; Epilepsy; Citric acid cycle; Epileptogenesis; Biology; Medicine; Endocrinology; Neuroscience; Biochemistry; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002359562,0.0003237227,0.0004962463,0.00006926045,0.00009870059,0.00002753232,0.0001404562,0.0002290948,0.00003240101],"category_scores_gemma":[0.0000422991,0.000260759,0.00006844321,0.00006012857,0.00009191495,0.000001435722,0.0002225905,0.00007418321,0.00002801559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002348458,"about_ca_system_score_gemma":0.0002852885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004089442,"about_ca_topic_score_gemma":0.000009976507,"domain_scores_codex":[0.9987381,0.00006038185,0.0003364588,0.0005241522,0.00007663447,0.0002642781],"domain_scores_gemma":[0.9994677,0.00001236954,0.0001087359,0.0002402092,0.00001932615,0.0001516405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003215615,0.00002285603,0.00002559471,0.001365379,0.00004701855,0.000002199014,0.0000846158,1.71328e-8,0.00001500592,0.0001439006,0.001736337,0.9965538],"study_design_scores_gemma":[0.0001803797,0.00002814891,0.0001019698,0.0002879916,0.00004931038,0.00003074115,0.00001813564,1.058019e-7,0.00009241623,0.00003385865,0.9988177,0.0003592558],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008897504,0.9965968,0.0001666659,0.000008770262,0.000105844,0.0003117696,0.00001202706,0.000008447756,0.00189993],"genre_scores_gemma":[0.00003966799,0.9960833,0.00205415,0.0002182247,0.00004813761,0.00006799003,0.0001869217,0.00003111199,0.001270552],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9970813,"threshold_uncertainty_score":0.9999844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03099500060022706,"score_gpt":0.2789958987754205,"score_spread":0.2480008981751934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}