{"id":"W2150567242","doi":"10.1200/jco.2006.08.8229","title":"<i>CHEK2</i> Mutation and Hereditary Breast Cancer","year":2006,"lang":"en","type":"letter","venue":"Journal of Clinical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Coalition for Research in Women's Health","funders":"","keywords":"Medicine; CHEK2; Breast cancer; Mutation; Cancer; Oncology; Internal medicine; Germline mutation; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007319053,0.0009346335,0.001642078,0.0007313695,0.00157965,0.001346743,0.001149995,0.02117101,0.008767],"category_scores_gemma":[0.006283545,0.0005638298,0.0008710311,0.0006962698,0.001209886,0.001308502,0.0004496938,0.008692151,0.003165288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002129003,"about_ca_system_score_gemma":0.0007706728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001995324,"about_ca_topic_score_gemma":0.003275287,"domain_scores_codex":[0.9994202,0.0001939106,0.00005790458,0.0000745334,0.0001355359,0.0001179484],"domain_scores_gemma":[0.9984254,0.0008442712,0.0001408002,0.00009463101,0.0001750841,0.0003198716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007296804,0.0001820737,0.00996657,0.0001972194,0.0001020636,0.157188,0.0001503997,0.0003512104,0.00142402,0.005550115,0.8046685,0.01949016],"study_design_scores_gemma":[0.001113993,0.0006839609,0.02430142,0.0005007488,0.0004597926,0.3567148,0.0005219443,0.006257985,0.003214445,0.0162182,0.5898911,0.0001217077],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02286166,0.008784651,0.0005892061,0.8906557,0.03255302,0.00006659216,0.000384988,0.000198461,0.04390569],"genre_scores_gemma":[0.253924,0.01059147,0.001622976,0.4864321,0.1840328,0.0001725548,0.0005125231,0.0001573401,0.06255434],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02117101,"threshold_uncertainty_score":0.02932858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04319344103746432,"score_gpt":0.4053422227949283,"score_spread":0.362148781757464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}