{"id":"W2150600032","doi":"10.1038/ng.2656","title":"Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis","year":2013,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":482,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Centre for Disease Control","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health; National Center for Chronic Disease Prevention and Health Promotion; Howard Hughes Medical Institute","keywords":"Tuberculosis; Mycobacterium tuberculosis; Biology; Mutation rate; Lineage (genetic); Drug resistance; Mutation; Antibiotics; Microbiology; Genetics; Virology; Gene; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003041108,0.0004526394,0.0004595614,0.001170136,0.0003552137,0.001244187,0.0005844877,0.001202592,0.001050161],"category_scores_gemma":[0.009488662,0.0004244739,0.0005105878,0.000724737,0.0004534071,0.0006948787,0.0005497178,0.00116324,0.0004824513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003029792,"about_ca_system_score_gemma":0.0001194367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000895466,"about_ca_topic_score_gemma":0.001339132,"domain_scores_codex":[0.9985195,0.0006492154,0.0001294027,0.0003668735,0.0001871169,0.0001479086],"domain_scores_gemma":[0.99237,0.004344148,0.001657243,0.0007869995,0.00056609,0.0002755587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007090596,0.00006500318,0.924495,0.00004471908,0.0003795784,0.000171725,0.0004444138,0.002718701,0.05955134,0.0005146725,0.0001911053,0.01071476],"study_design_scores_gemma":[0.00003373107,0.0001707628,0.9770321,0.0000300894,0.000152555,0.0007745704,0.0003480194,0.01180754,0.007972534,0.001121883,0.0005250832,0.00003115223],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976037,0.0003132211,0.001433016,0.00005136036,0.000005933849,0.000004094057,0.0001621214,0.00001537458,0.0004111908],"genre_scores_gemma":[0.9992205,0.00005671865,0.0004739321,0.00003986893,0.000004280734,0.00000160142,0.0001581074,0.00001135071,0.00003354459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003041108,"threshold_uncertainty_score":0.01608306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01631119637757917,"score_gpt":0.2918378280061364,"score_spread":0.2755266316285573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}