{"id":"W2150611269","doi":"10.1128/aac.01570-09","title":"Nucleotide Selectivity of Antibiotic Kinases","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Enzyme; Kinase; Biochemistry; GTP'; Nucleotide; Antibiotics; Biology; Aminoglycoside; Phosphotransferases; Antibiotic resistance; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003077184,0.0004361235,0.0004244399,0.000169902,0.0001931865,0.0008905059,0.0003653639,0.0005236771,0.00211417],"category_scores_gemma":[0.001027302,0.0002042097,0.0001422535,0.0001664357,0.0002297252,0.0005377395,0.000354689,0.0006219518,0.000935578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006092109,"about_ca_system_score_gemma":0.0003544875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006948506,"about_ca_topic_score_gemma":0.0007360847,"domain_scores_codex":[0.999357,0.0001126135,0.00005192561,0.0002056775,0.000178394,0.00009443762],"domain_scores_gemma":[0.9995531,0.0001879101,0.00007072126,0.0000322606,0.00009786217,0.00005803026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001365714,0.00001566445,0.0005532531,0.00007512783,0.000005164398,0.00004205834,0.00002034854,0.0001886435,0.994034,0.0005143078,0.00008744878,0.00432731],"study_design_scores_gemma":[0.00000886661,0.0001415495,0.001812169,0.000007877633,0.000008768302,0.0004648865,0.00002293658,0.001644333,0.990535,0.00022903,0.005115055,0.000009610884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623088,0.008774379,0.01382423,0.0003906288,0.0001042753,0.00006667179,0.0007620801,0.0002117817,0.01355729],"genre_scores_gemma":[0.9901047,0.001860154,0.004770004,0.0001396194,0.00002027389,0.00003746333,0.000626207,0.00005274286,0.002388811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00211417,"threshold_uncertainty_score":0.007072628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005714829441555194,"score_gpt":0.2379355811509408,"score_spread":0.2322207517093856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}