{"id":"W2150612042","doi":"10.1126/scisignal.2005824","title":"A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells","year":2015,"lang":"en","type":"article","venue":"Science Signaling","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"American Heart Association; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Intracellular; Cell biology; Signature (topology); Smooth muscle; Channel (broadcasting); Chemistry; Biology; Endocrinology; Computer science; Computer network","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001195424,0.0001992447,0.0001724671,0.0001106524,0.0001565553,0.000199059,0.000135685,0.0002228636,0.001369826],"category_scores_gemma":[0.0001676371,0.00008568623,0.0001897136,0.00008948125,0.0002220113,0.0001733027,0.0001755441,0.0003648482,0.0003400331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000230298,"about_ca_system_score_gemma":0.000160372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002378429,"about_ca_topic_score_gemma":0.0003631604,"domain_scores_codex":[0.9999068,0.00001633949,0.00001174284,0.00002542277,0.00002181872,0.00001786068],"domain_scores_gemma":[0.9998409,0.00002507378,0.00006363908,0.00001480735,0.00000979707,0.0000458756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004969906,0.000006153521,0.0001388931,0.000009877548,0.000001897607,0.00006377276,0.000005076537,0.00005467496,0.9990587,0.0001299325,0.00001081009,0.0004705731],"study_design_scores_gemma":[0.00002690275,0.0002367416,0.00989202,0.000006182801,0.0000142651,0.0009719772,0.00001661773,0.001505972,0.9852977,0.0001178887,0.001906876,0.000006870117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960007,0.0002995293,0.002726219,0.00008507406,0.00002613593,0.00001648947,0.0001434795,0.0000540545,0.0006484107],"genre_scores_gemma":[0.996653,0.0001609215,0.002121726,0.00005245724,0.000009328342,0.00001555577,0.0002254645,0.0000147283,0.0007467152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001369826,"threshold_uncertainty_score":0.004582524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01496146190068813,"score_gpt":0.2428806666540802,"score_spread":0.227919204753392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}