{"id":"W2150626960","doi":"10.1158/1538-7445.am2014-3450","title":"Abstract 3450: Internalization and recycling of RET receptor tyrosine kinase isoforms","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Biology; Cell biology; Receptor tyrosine kinase; Internalization; Tyrosine kinase; Endosome; Proto-oncogene tyrosine-protein kinase Src; Cancer research; Gene isoform; Clathrin; Signal transduction; Receptor; Intracellular; Endocytosis; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001285551,0.0003198006,0.0001606544,0.000231978,0.0002262065,0.0003231138,0.0002203047,0.0003434858,0.002205833],"category_scores_gemma":[0.0001093472,0.0001361233,0.000405293,0.0001957074,0.0001265818,0.0002405043,0.0002156823,0.0003705206,0.0008779056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004085935,"about_ca_system_score_gemma":0.0002119684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001490451,"about_ca_topic_score_gemma":0.001013033,"domain_scores_codex":[0.9998484,0.00001987439,0.00001173845,0.00003401533,0.00004954793,0.0000365131],"domain_scores_gemma":[0.9999522,0.000007690811,0.000008777664,0.000005637954,0.00001691036,0.000008782445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008314481,0.000006042038,0.0002099326,0.00003492356,0.000003550745,0.00009315577,0.00001648274,0.00002803116,0.9981099,0.0001590542,0.00006317515,0.0011925],"study_design_scores_gemma":[0.00001491576,0.0002505457,0.01450339,0.00001584943,0.00003254888,0.001345413,0.00008042691,0.0009825364,0.974349,0.0001410189,0.008271361,0.0000131746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831089,0.006250235,0.00427597,0.0001198441,0.00006467387,0.00003477848,0.0006017155,0.00007154356,0.005472284],"genre_scores_gemma":[0.9808182,0.00212378,0.002890549,0.000107658,0.00001921873,0.00003299744,0.001501131,0.00003211171,0.01247437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002205833,"threshold_uncertainty_score":0.007379174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04650462885011818,"score_gpt":0.3822201301614986,"score_spread":0.3357155013113804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}