{"id":"W2150667753","doi":"10.1093/nar/29.4.960","title":"Rapid evolution of the DNA-binding site in LAGLIDADG homing endonucleases","year":2001,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Biology; Homing endonuclease; Subfamily; Genetics; DNA; Intron; Restriction enzyme; Peptide sequence; Sequence motif; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002943641,0.0002408169,0.0003599726,0.0006035771,0.0002764722,0.0004948223,0.0002530963,0.0004646044,0.0002830642],"category_scores_gemma":[0.0006467263,0.000257651,0.000218438,0.0004206276,0.000320546,0.0003278202,0.0003608706,0.0006027228,0.0003382991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004834463,"about_ca_system_score_gemma":0.0002250073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006447776,"about_ca_topic_score_gemma":0.0007643583,"domain_scores_codex":[0.9997777,0.00002188939,0.00001604905,0.00008751915,0.00004794625,0.00004888678],"domain_scores_gemma":[0.9993993,0.0001093892,0.000183792,0.00008892859,0.00007815043,0.0001403771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001276467,0.0000258234,0.01479239,0.00003629533,0.0000133066,0.0001300877,0.0001151593,0.0002097391,0.977566,0.0002121815,0.00001949395,0.006751969],"study_design_scores_gemma":[0.00006296991,0.0006573785,0.5642322,0.00007407219,0.0001362182,0.004791645,0.0004949973,0.004174983,0.4145916,0.001047085,0.009664221,0.00007266444],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977534,0.000498536,0.001409519,0.00002799601,0.000002978818,0.000005588064,0.00006360615,0.00002220521,0.0002162577],"genre_scores_gemma":[0.9962258,0.0002607629,0.002691537,0.00005007355,0.000006288766,0.000009488077,0.0003714844,0.0000125343,0.0003719307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006447776,"threshold_uncertainty_score":0.003507733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0341337560170911,"score_gpt":0.2986506295161301,"score_spread":0.264516873499039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}