{"id":"W2150701651","doi":"10.1016/s1535-6108(03)00241-1","title":"VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents","year":2003,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":848,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Montréal; McGill University; Terry Fox Research Institute; University of Ottawa; Ottawa Regional Cancer Foundation","funders":"Canadian Institutes of Health Research; Cancer Care Ontario","keywords":"Oncolytic virus; Vesicular stomatitis virus; Innate immune system; Lytic cycle; Ovarian cancer; Biology; Cancer; Interferon; Immunity; Cancer cell; Clearance; Cancer research; Immune system; Immunology; Vesicular Stomatitis; Virology; Virus; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002411348,0.0005740019,0.0004754046,0.0003644605,0.0001789933,0.0004114794,0.0003257903,0.0004547889,0.00153013],"category_scores_gemma":[0.0001645044,0.000162753,0.0002741215,0.0002755246,0.0003878135,0.0002782832,0.0001803651,0.001224025,0.0004259731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004369748,"about_ca_system_score_gemma":0.0002801891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005986938,"about_ca_topic_score_gemma":0.001256937,"domain_scores_codex":[0.9997873,0.0000352044,0.00001688799,0.00002493078,0.0000761153,0.00005951605],"domain_scores_gemma":[0.9998301,0.00004374829,0.00004283328,0.00003110792,0.00001690196,0.00003529813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001658171,0.00006516859,0.0001471283,0.00002314263,0.00001040128,0.00003335086,0.000008992901,0.0001596285,0.9966201,0.0006519237,0.000155634,0.001958687],"study_design_scores_gemma":[0.00003399025,0.000461277,0.0009758504,0.000003442802,0.00001656921,0.0001998141,0.00001522304,0.0004777271,0.9947825,0.00009898159,0.002929564,0.000004975548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877985,0.002177094,0.006079573,0.0001934417,0.0001795475,0.00007775606,0.0007174094,0.0002178598,0.00255867],"genre_scores_gemma":[0.9914842,0.001050314,0.003209824,0.00005491984,0.00003663869,0.00006221803,0.0009480022,0.00005000599,0.003103891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00153013,"threshold_uncertainty_score":0.005118847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02368840543473547,"score_gpt":0.2937026590417071,"score_spread":0.2700142536069716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}