{"id":"W2150705064","doi":"10.1186/1758-3284-3-11","title":"The association between EGFR variant III, HPV, p16, c-MET, EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck","year":2011,"lang":"en","type":"article","venue":"Head & Neck Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Pfizer Canada; Pfizer","keywords":"Erlotinib; Medicine; Epidermal growth factor receptor; EGFR inhibitors; Oncology; Cancer research; Immunohistochemistry; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003736852,0.0001482162,0.0003175554,0.0003304556,0.0001630768,0.0002607842,0.0001663086,0.0003486829,0.0009327471],"category_scores_gemma":[0.001018913,0.00008900197,0.0002619172,0.0003120846,0.0002083196,0.0001944281,0.0001104273,0.0002767351,0.0001233979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002467508,"about_ca_system_score_gemma":0.0001776757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008512087,"about_ca_topic_score_gemma":0.001147471,"domain_scores_codex":[0.9998491,0.00002814003,0.00002017578,0.00004032318,0.00003412973,0.0000282108],"domain_scores_gemma":[0.9993112,0.0002692017,0.0002217572,0.00003788069,0.00005023826,0.0001096021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001174234,0.00003911678,0.993867,0.00001281538,0.00007192681,0.0001089806,0.00002545623,0.0001298844,0.001979556,0.000005950118,0.00004266382,0.002542431],"study_design_scores_gemma":[0.00003271315,0.0007329048,0.9973435,0.000002731841,0.00007025777,0.0008273417,0.00003325462,0.000286587,0.0005295257,0.00001300466,0.0001253533,0.000002908049],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995092,0.0002607578,0.00003022422,0.000009689943,0.00000162377,0.000003464218,0.00007569439,0.00000143888,0.0001078006],"genre_scores_gemma":[0.9997862,0.00003712061,0.00002623399,0.000007255117,0.000003853598,0.000003215741,0.00009746803,5.485469e-7,0.00003817067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009327471,"threshold_uncertainty_score":0.003120363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02876058298546944,"score_gpt":0.3004235876969513,"score_spread":0.2716630047114818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}